Nick Shaw and Dr. Eric Trexler discuss oral GLP-1 options, how the newer drugs compare, and practical questions about dosing, side effects, muscle retention, and possible benefits beyond weight loss. They also examine research on weight regain after stopping treatment, the cost of long-term access, and how these medications may affect food cravings and behavior.
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Dr. Eric Trexler's Links:
Instagram: https://www.instagram.com/trexlerfitness/
ResearchGate: https://www.researchgate.net/profile/Eric-Trexler
MASS Research Review: https://massresearchreview.com/
00:00:00 Intro and football banter
00:03:21 Why GLP-1s are everywhere
00:08:17 Dosing and tolerability
00:11:12 Oral GLP-1 options
00:17:55 Single, dual, and triple agonists
00:21:59 How much weight loss do trials show?
00:26:53 Side effects and protecting muscle
00:31:34 Health effects beyond weight loss
00:34:53 Reward, cravings, and enjoyment
00:46:05 Weight regain after stopping
00:50:42 Cost and long-term access
00:53:57 What wider access could change