Alzheimer’s looks very different from obesity, which we think of as different from stroke, depression, or infertility. But according to Dr. Casey Means, the root cause of our most common chronic diseases can be traced to metabolic dysfunction. In this episode, she and Jeff discuss what your blood sugar is trying to tell you — including the data your doctor i ... Show More
Jun 4
The Menopause Gut: How Hormones Shape Your Microbiome with Cynthia Thurlow
What happens to your gut when estrogen declines? In this episode, Jeff sits down with Cynthia Thurlow, nurse practitioner and author of The Menopause Gut, to explore the overlooked connection between hormones and digestive health. How declining estradiol impacts the microbiome an ... Show More
1h 7m
Jun 2
Is This Right for Me? NAD+: Why the "Longevity Molecule" Story Just Got Complicated
NAD+ has become the longevity industry's favorite molecule, sold as as a supplement and as a four-hour IV that promises sharper thinking, more energy, and slower aging. But a new 2026 paper complicates the very story it was built on. In this episode, Jeff breaks down what NAD+ ac ... Show More
51m 30s
May 28
Waking Up with Sam Harris: Mindfulness, Non-Duality, and the Illusion of the Self
How do you regulate your nervous system in a world built to hijack it? In this episode, Jeff sits down with Sam Harris, neuroscientist, author, and creator of the Waking Up meditation app, for part two of a two-part conversation. After diagnosing the political chaos in part one, ... Show More
55m 1s
Nov 2020
Digital Tools to Measure Blood Sugar & Metabolic Health with Dr Casey Means
<p><span style="font-weight: 400;">Today's episode is proudly sponsored by Pique Tea - pure, effective, accessible designed for radiant health. I depend on their Fasting Teas to curb cravings and boost energy and focus - they're delicious, effective, and don't break my fast. Get ... Show More
1h 2m
Jun 2025
177. Dr. Judith Joseph: How to Recognize High Functioning Depression Signs and Find Treatment
Crushing it professionally, but feeling empty inside? This is what Dr. Judith Joseph calls, “high-functioning depression.” Here’s what’s really happening: You’re pathologically productive, wearing a mask of success while experiencing anhedonia — the clinical term for losing joy i ... Show More
1h 15m
Dec 2024
Transform Your Energy: From Metabolism to Mitochondria with Dr. Casey Means
"Good energy is fundamentally about giving your body what it needs to thrive. When we do this, our cells work better, our hormones balance, and we feel absolutely incredible." - Dr. Casey Means
In this eye-opening episode, I sat down with Dr. Casey Means, Stanford-trained physic ... Show More
1h 32m
Feb 2025
141. Max Lugavere: Seed Oils, LDL Cholesterol & Inflammation
What if everything you thought you knew about “heart-healthy” cooking oils was based on outdated science and clever marketing? In this episode, I’ve sat down once again with Max Lugavere, and we’ve had an amazing conversation about the metabolic chaos that modern seed oils are si ... Show More
1h 3m
Oct 2025
213. Rose Ferguson: Q&A on MTHFR Gene Mutation, Autoimmune Disease, Cognitive Decline, & More!
Think gluten is your enemy? The real culprit behind your sensitivity might shock you, and it’s hiding in almost every processed food labeled as “enriched” or “fortified.” In this unfiltered nutritional Q&A, Rose Ferguson and I answered questions on chronic disease, cognitive decl ... Show More
1h 5m
Mar 2025
149. Kayla Barnes: The Science of Female Biohacking - Gut Health, Toxins, and Menstrual Cycles
Most biohacking conversations are dominated by men talking to other men. But they’re missing a critical perspective - female biology requires a completely different approach. In this episode, I’ve had an amazing conversation with Kayla Barnes, a true pioneer in female-focused bio ... Show More
1h 18m