In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all ... Show More
Aug 7
How to Exercise to Live Longer | Lifespan with Dr. David Sinclair - S2, Ep. 5
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube ... Show More
1h 9m
Jul 23
Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube ... Show More
1h 12m
Jul 12
What to Eat & When to Eat for Longevity: New Science | Lifespan with Dr. David Sinclair - S2, Ep. 3
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives - while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTu ... Show More
1h 8m
Sep 2019
#70 - David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD)
<p>In this episode, David Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, returns to the podcast to discuss the content of his new book, Lifespan: Why We Age - ... Show More
2h 10m
Dec 2021
The Biology of Slowing & Reversing Aging | Dr. David Sinclair
In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Po ... Show More
2h 7m
Oct 2024
Unlocking the Secrets of Longevity with Dr. David Sinclair
<p>In this episode of Longevity by Design, our host Dr. Gil Blander speaks with Dr. David Sinclair, a professor of genetics at Harvard Medical School, about the science behind aging and how we can extend both lifespan and healthspan. Dr. Sinclair shares his groundbreaking researc ... Show More
46m 23s
Oct 2025
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging. We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, reg ... Show More
39m 7s
Oct 2022
Why We Grow Old And How To Age Well
This episode is brought to you by Rupa Health, ButcherBox, and InsideTracker. In Western culture, we’ve gained a negative view of aging. But in other cultures around the world, aging is celebrated and embraced. That’s because we define difficult symptoms like aches and pains, cog ... Show More
59 m
Feb 2023
What Actually Causes Aging?
This episode is brought to you by Rupa Health and Athletic Greens. To understand and combat rapid aging, we need to understand what causes aging, chronic diseases, and decline. We call these things the hallmarks of aging—the underlying common pathways or mechanisms of aging. Each ... Show More
38m 38s