logo
episode-header-image
Dec 2017
1h 3m

#040 Dr. Eric Verdin on Ketogenic Diet L...

RHONDA PATRICK, PH.D.
About this episode

Eric M. Verdin

Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF.

Dr. Verdin's laboratory focuses on the role of epigenetic regulators in the aging process, the role of metabolism and diet in aging and on the chronic diseases of aging, including Alzheimer’s, proteins that play a central role in linking caloric restriction to increased healthspan, and more recently a topic near and dear to many of you, ketogenesis. He's held faculty positions at the University of Brussels, the NIH and the Picower Institute for Medical Research.

 In this episode, you'll discover:

  • (00:00) Introduction
  • (07:32) Interventions to prolong lifespan
  • (10:42) The role of insulin pathways in aging
  • (16:25) HDAC inhibition by ketones
  • (27:52) Protein activates mTOR & IGF-1
  • (30:28) PPAR-alpha activation facilitates benefits of a ketogenic diet
  • (35:28) What biomarkers can predict aging?
  • (39:38) Cellular NAD+ levels decrease with age 
  • (52:47) Ketogenic diet safety 
  • (56:07) Intermittent fasting as an alternative to a keto diet

If you’re interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information on ketogenic diet & longevity straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Up next
Oct 2
#107 How To Cure Insomnia & Fall Asleep Fast | Dr. Michael Grandner
<p><a href= "https://www.foundmyfitness.com/ask-me-anything?utm_campaign=michael_grandner_podcast&utm_medium=podcast&utm_source=podcast_description"> Get access to <strong>more than 70 Ask Me Anything episodes</strong> with Dr. Rhonda Patrick when you sign up as a FoundMyFitness ... Show More
3h 44m
Sep 5
#106 How To Increase Your Testosterone Levels Naturally | Derek from MPMD
<p dir="ltr"><a href= "https://www.foundmyfitness.com/ask-me-anything?utm_campaign=derek_mpmd_podcast&utm_medium=podcast&utm_source=podcast_description"> Get access to <strong>more than 70 Ask Me Anything episodes</strong> with Dr. Rhonda Patrick when you sign up as a FoundMyFitn ... Show More
3h 16m
Aug 5
#105 Exogenous ketones, my coffee protocol, and supplements for blood sugar regulation (Premium Member Q&A July 2025)
<p data-start="106" data-end="767"><a href= "https://www.foundmyfitness.com/crowdsponsor?utm_campaign=qa_72_public&utm_medium=podcast&utm_source=podcast_description"> <strong data-start="106" data-end="274">Become a FoundMyFitness Premium Member to access the full episode</strong ... Show More
33m 5s
Recommended Episodes
Aug 2022
Exercise, Nutrition, Hormones for Vitality & Longevity | Dr. Peter Attia
My guest this episode is Dr. Peter Attia, M.D., who trained at Stanford University School of Medicine, Johns Hopkins Hospital and the National Institutes of Health (NIH). Dr. Attia is host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventi ... Show More
2h 47m
Jul 2023
Unlocking Longevity With Four Essential Foods and Anti-Aging Strategies EP 1465
<p>The Summit of Greatness is back! Buy your tickets today – <a href="https://www.summitofgreatness.com/">summitofgreatness.com</a> – </p><p>Dr. Rhonda Patrick has a Ph.D. in biomedical science and has done extensive research on nutrition, aging, stress, and cancer. She trained a ... Show More
57m 16s
Dec 2021
The Biology of Slowing & Reversing Aging | Dr. David Sinclair
In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Po ... Show More
2h 7m
Sep 2023
How the Right Nutrition and Supplements Can Transform Your life | Avgoustinos Mesaritis
Send us a text🎙️ Embark on an enlightening journey with Avgoustinos Mesaritis, a seasoned nutritionist and naturopath, as we explore the fascinating world of nutrition and supplements. Discover evidence-based insights, gain practical advice, and unravel the truth behind these di ... Show More
1h 17m
Feb 2024
Dr. Nir Barzilai: Can This Drug Slow Aging? The Science Behind Metformin
View the Show Notes For This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal Get Ad-free Episodes & Dr. Hyman+ Audio Exclusives Dr. Nir Barzilai is a geroscientist, Chaired Professor of Medicine and Genetics, and the founder and ... Show More
1h 51m
Apr 2023
#208 - A low-carb diet may boost exercise performance and health | Professor Tim Noakes & Josh Clemente
<p>High-carbohydrate diets and carbohydrate loading have been long-standing tenets of athletic training and competition, but newer research indicates a low-carbohydrate diet may be more beneficial for performance and overall health. Professor Tim Noakes and Josh Clemente discuss ... Show More
1h 4m
Jan 2022
What to Eat & When to Eat for Longevity | Episode 2
In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a "low energy state," which can be induced by a period of fasting, combats aging a ... Show More
1h 7m
Jan 2022
Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3
In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exerci ... Show More
1h 11m
Sep 2023
#229 - Nature Wants Us to Be Fat | Dr. Casey Means & Dr. Richard Johnson - (Replay)
<p>Dr. Casey Means, Chief Medical Officer of Levels speaks with Dr. Richard Johnson about his book, &quot;Nature Wants Us to Be Fat,&quot; as well as his insights on the &quot;survival switch&quot; that drives our body to store fat in response to certain conditions like high fruc ... Show More
1h 12m
Jan 2022
NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4
In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidi ... Show More
1h 10m