logo
episode-header-image
May 2023
2h 29m

#252 ‒ Latest insights on Alzheimer's di...

Peter Attia, MD
About this episode

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter's Weekly Newsletter

Rhonda Patrick, Ph.D., is a scientist with expertise in the areas of aging, cancer, and nutrition who translates complex scientific topics into actionable insights on her podcast, Found My Fitness. In this episode, Rhonda provides her latest thinking as it relates to Alzheimer's disease including the possibility of a vascular hypothesis as well as the factors that can impact disease risk such as type 2 diabetes, blood pressure, omega supplementation, exercise, sauna, and more. She also touches on cancer risk including the relationship between cancer and exercise as well as the link between alcohol consumption and cancer. Additionally, Rhonda explains her new focus on exercise and protein consumption as well as how her perspective has shifted as it pertains to fasting and time-restricted feeding.

We discuss:

  • Alzheimer's disease: Rhonda's evolved thinking on neurodegenerative diseases [2:30];
  • The breakdown of the blood-brain barrier in neurodegenerative disease [8:45];
  • An explanation for the observation that type 2 diabetes increases risk of Alzheimer's disease [15:45];
  • The role of omega-3 fatty acids (EPA and DHA) in brain health and prevention of neurodegeneration [19:45];
  • Comparing the preventable nature of type 2 diabetes, atherosclerosis, cancer, and dementia [32:15];
  • Blood pressure: an important modifiable lifestyle factor that can affect Alzheimer's disease risk [35:15];
  • Rhonda's outlook on "precision medicine" as it pertains to one's genetic predispositions [38:45];
  • Possible mechanisms by which exercise reduces the risk of Alzheimer's disease [45:45];
  • Building your aerobic pyramid: neurobiological effects of exercise, benefits of lactate peaks, and more [53:45];
  • Maximizing mitochondrial biogenesis: alternative training approaches and strategies [58:45];
  • Possible brain benefits of sauna, and Rhonda's personal protocol [1:09:30];
  • The relationship between cardiorespiratory fitness and dementia risk [1:15:30];
  • How exercise may reduce the risk of cancer [1:20:30];
  • The overarching impact of exercise on health, and the importance of focusing the factors that matter most [1:33:15];
  • Impact of alcohol consumption on breast cancer risk and overall health [1:37:15];
  • Exercise as an intervention for poor sleep habits [1:42:30];
  • The longevity benefits of consuming adequate protein and strength training to preserve muscle mass and strength [1:46:30];
  • How to get enough of the right kind of protein in your diet [2:05:15];
  • Fasting: weighing the risk vs. reward [2:12:15];
  • How Rhonda's views have shifted on diet and exercise [2:15:30];
  • How to follow Rhonda's work and more about the benefits of lactate for the brain [2:21:00]; and
  • More.

Connect With Peter on TwitterInstagramFacebook and YouTube

Up next
Today
The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green (#288 rebroadcast)
<p><a href= "https://peterattiamd.com/waltergreen/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=251124-pod-waltergreen&utm_content=251124-pod-waltergreen-podfeed"> View the Show Notes Page for This Episode</a></p> <p><a href= "https://peterattiamd.com/subscribe/?utm_s ... Show More
1h 31m
Nov 17
#373 – Thyroid function and hypothyroidism: why current diagnosis and treatment fall short for many, and how new approaches are transforming care | Antonio Bianco, M.D., Ph.D.
<p><a href= "https://peterattiamd.com/antoniobianco/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=251117-pod-antoniobianco&utm_content=251117-pod-antoniobianco-podfeed"> View the Show Notes Page for This Episode</a></p> <p><a href= "https://peterattiamd.com/subscribe/ ... Show More
2h 20m
Nov 10
#372 - AMA #77: Dietary fiber and health outcomes: real benefits, overhyped claims, and practical applications
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter breaks down the science of dietary fiber, moving beyond the blanket advice to "eat more fiber" to unc ... Show More
24m 14s
Recommended Episodes
Nov 2023
#083 How Vitamin D, Omega-3s, & Exercise May Increase Longevity | Dr. Rhonda Patrick
<p>This episode features Rhonda Patrick, Ph.D., and was originally recorded for the Institute for Functional Medicine's podcast, 'Pathways to Wellbeing.' This episode outlines a series of fundamental tactics you can start applying immediately to enhance cellular health, protect t ... Show More
1 h
Dec 2023
#085 Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging
<p><a href= "https://bdnfprotocols.com?utm_campaign=vig_ex_podcast&utm_medium=podcast&utm_source=podcast_description"> Download the 9-Page "<strong>Cognitive Enhancement Blueprint</strong>"</a></p> <p dir="ltr"><a href= "https://www.foundmyfitness.com/aliquot?utm_campaign=peter_a ... Show More
3h 59m
Feb 2023
#079 Blood-Brain Barrier Dysfunction in Alzheimer’s Disease and Dementia | Axel Montagne, Ph.D.
<p>Dr. Axel Montagne is a chancellor's fellow and group leader at the UK Dementia Research Institute at the University of Edinburgh Centre for Clinical Brain Sciences. His group aims to understand how, when, and where critical components of the <strong>blood-brain barrier</strong ... Show More
1h 48m
Dec 2023
#084 The Longevity & Brain Benefits of Vigorous Exercise | Dr. Rhonda Patrick
<p><a href= "https://bdnfprotocols.com?utm_campaign=vig_ex_podcast&utm_medium=podcast&utm_source=podcast_description"> Download the 9-Page "<strong>Cognitive Enhancement Blueprint</strong>" companion guide at <strong>bdnfprotocols.com</strong>.</a></p> <p>This episode challenges ... Show More
1h 2m
Mar 2024
#086 How Micronutrients & Exercise Ameliorate Aging | Dr. Rhonda Patrick
<p><a href= "https://bdnfprotocols.com/?utm_campaign=longevity_fest_pod&utm_medium=podcast&utm_source=podcast_description"> Download the 9-Page "<strong>Cognitive Enhancement Blueprint</strong>"</a></p> <p dir="ltr"><a href= "https://www.foundmyfitness.com/aliquot?utm_campaign=lo ... Show More
56m 59s
Feb 2024
#512: Alzheimer's Disease – Drs. Ayesha & Dean Sherzai
<p><strong><span style= "font-size: 18pt;">Links:</span></strong></p> <ul> <li><a href="https://sigmanutrition.com/episode512/">Go to episode page (with episode resources)</a></li> <li><a href="https://sigmanutrition.com/premium/">Subscribe to PREMIUM</a></li> <li><a href="https: ... Show More
1h 10m
Nov 2022
Diet & Nutrition for Mental Health | Dr. Chris Palmer
My guest this episode is Chris Palmer, M.D., a board-certified psychiatrist and assistant professor of psychiatry at Harvard Medical School. He explains the important connection between nutrition, metabolism and mental health and his pioneering work using the ketogenic diet to su ... Show More
3 h
Jan 2022
The 5 Main Ways To Prevent Alzheimer's & Dementia
This episode is brought to you by Rupa Health and Paleovalley. Protecting your brain and cognitive function is not just for the elderly. It’s never too early to start protecting your brain, which is something we should all think more about as Alzheimer’s and dementia rates contin ... Show More
1h 12m
Aug 2021
#066 Dr. Mark Mattson on the Benefits of Stress, Metabolic Switching, Fasting, and Hormesis
<p><strong>Dr. Mark Mattson</strong></p> <p>Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientis ... Show More
2h 20m
Mar 2023
Improve Vitality, Emotional & Physical Health & Lifespan | Dr. Peter Attia
In this episode, my guest is Peter Attia, M.D. He completed his medical and advanced training at Stanford University School of Medicine, Johns Hopkins School of Medicine and the National Institutes of Health (NIH). Dr. Attia is host of the health and medicine podcast, The Drive,  ... Show More
3h 25m