Most anti-aging skincare focuses on wrinkles after they appear. Skin longevity starts much earlier, with the biology that determines how well skin repairs itself, maintains collagen, responds to hormones, and clears damaged or senescent cells.
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I sat down with Dr. Saranya Wyles, MD, PhD, a Mayo Clinic dermatologist and regenerative medicine researcher, to separate useful science from a category full of hype. We cover sunscreen, visible light, facial estrogen, exercise, sauna, Botox, microcurrent, radiofrequency, retinol, exosomes, and the treatments that may support healthier skin over time.
We also explore why women's skin changes during menopause and across the menstrual cycle, how bone and facial fat influence visible aging, and why the right intervention depends on the decade, the tissue, and the problem you are actually trying to solve.
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In This Conversation:
How senescent cells affect skin aging and repair
Why menopause accelerates collagen and skin changes
What sunscreen, antioxidants, and physical barriers actually do
Botox, facial exercises, microcurrent, and in-office devices
Retinol, exosomes, PRP, and regenerative skincare
How exercise, sleep, sauna, and the microbiome affect skin
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Learn More About Dr. Saranya Wyles:
Mayo Clinic Profile: https://www.mayoclinic.org/biographies/wyles-saranya-p-m-d-ph-d/bio-20518649
Instagram: https://www.instagram.com/drwyles.derm/
LinkedIn: Saranya Wyles, M.D., Ph.D. | LinkedIn
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