In this episode, Sam Ashoo, MD, Dr. Christopher Baugh, MD, MBA, and Dr. Xin Qi, MD, discuss the October 2026 Emergency Medicine Practice article, Antithrombotic-Associated Bleeding: Management in the Emergency Department.
1:18 — Guest introductions
1:58 — Why the authors chose this topic
3:11 — Epidemiology
4:27 — Why DOACs over warfarin
5:15 — Bleeding trends
6:55 — Overlapping antithrombotic regimens
8:09 — Reversibility of agents
9:38 — Bedside priorities
11:31 — Bleeding patterns by drug class & three groups
13:50 — Antithrombotics & traumatic bleeding risk
14:26 — Pre-hospital considerations
16:09 — Indications for antithrombotic use & risk of reversing
17:54 — Gray-area decisions
19:02 — Initial resuscitation
20:08 — Blood product ratios
21:24 — PATCH trial
22:04 — TXA evidence
23:36 — GI bleed adjuncts
24:31 — Critical site bleeds
27:20 — Endoscopy timing
30:00 — Reversal agents
32:50 — Idarucizumab for dabigatran
33:54 — Antiplatelet reversal
36:15 — Warfarin reversal
38:36 — Protamine for heparin/LMWH
39:37 — Fibrinolytic reversal
40:14 — Pre-procedural antithrombotic management
42:39 — Emerging labs
43:50 — Wrap-up & closing promo
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