In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the July 2026 Emergency Medicine Practice article, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management in the Emergency Department.
- 0:17 – Intro & sponsor promo
- 1:09 – Episode introduction
- 4:03 – Definitions: SJS vs. TEN vs. "overlap" by body surface area
- 6:12 – Pathophysiology
- 9:52 – Incidence and rarity of the disease
- 10:53 – Differential diagnosis & clinical presentation clues
- 12:08 – Prehospital care & fluid resuscitation considerations
- 13:47 – ED history-taking: medications, infections, rash progression
- 14:47 – Physical exam findings
- 16:46 – Diagnostic studies
- 18:12 – Scoring systems: SCORTEN and ABCD-10
- 20:50 – Treatment goals
- 23:57 – Wound care principles
- 24:43 – Mechanical ventilation risk factors
- 26:02 – Other possible therapies
- 27:50 – Specialty consults & special populations
- 29:06 – Ophthalmologic treatment
- 31:17 – HIV patients and elevated risk
- 31:55 – Emerging therapies & AI-based diagnostic tools
- 32:57 – Five key clinical takeaways
- 34:37 – Closing remarks & sponsor sign-off
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