In this episode, Dr Paul Taylor talks with integrative practitioner Dr Christobelle Yeoh about protecting cognitive health. They start with the rise of early cognitive decline, brain fog and stress, including during menopause. Dr Yeoh's central idea is that thinking depends on the body. Cognition rests on the lower-order systems that feed the brainstem: the gut, vascular tone, blood chemistry, breathing and the cranial nerves that read signals of safety. They explain how chronic stress and the brain's constant threat prediction affect it. They also cover why top-down approaches like CBT work best alongside bottom-up, body-based ones. The second half is practical. They look at common mismatches and what to do about them: get morning sunlight and keep a circadian rhythm, eat at regular times in daylight hours and prioritise protein and whole foods, and fix the basics before relying on supplements such as DHA, creatine and ubiquinol. They also cover CO₂-tolerance breathing, and movement that challenges balance and coordination to support neuroplasticity.
Key takeaways
Time Stamps
0:59 Why cognitive health matters, with dementia now overtaking cardiovascular disease in Australia 1:34 What's going on: brain fog, early cognitive decline (MCI), and stress in menopause 4:02 Is getting more forgetful in your 40s, 50s and 60s a warning sign? 5:35 Reframing cognition as an emergent property of whole-system regulation 10:52 Chronic stress, the brain as a prediction engine, and early-life influences 17:20 Five key inputs to the brainstem: cranial nerves, gut, vascular tone, blood pH/redox, and breathing 21:59 Threat vs challenge stress appraisal, and cortisol vs adrenaline 24:48 Top-down (CBT, ACT) and bottom-up (body-based) approaches, and neuroplasticity 27:23 Functional brain networks, and why complex, cross-body movement matters 31:52 The big mismatches: circadian biology, supplements before fundamentals, cell membrane and bioelectricity, CO₂ tolerance, and psychology without physiology 40:31 Circadian basics: morning sunlight, "clocking in" with the sun, ditching sunglasses 43:30 Red and near-infrared light, and light-based therapy for neurodegenerative conditions 47:07 Food timing, protein and the protein leverage idea, seasonal eating, leptin and insulin resistance 51:54 Supplements: DHA, phospholipids, organ meats and liver capsules, electrolytes and minerals 54:09 Creatine and hydration, including the dehydration and cortisol study 57:14 Ubiquinol: dosing and its role in the electron transport chain 58:31 Urolithin A, B vitamins, and matching supplements to the person 1:00:12 Breathing: CO₂ tolerance and Buteyko-style training vs cathartic and holotropic breathwork 1:05:23 Psychology–physiology mismatch: somatic work, vitamin D, creatine and psychotherapy
Mentioned in this episode
Dr Dale Bredesen's work on reversing cognitive decline
Dr Stephen Porges (polyvagal theory and neuroception)
Prof. Mark Seery (challenge and threat appraisal)
Dr Konstantin Buteyko and Patrick McKeown (CO₂ tolerance breathing)
Dr Rosalba Courtney (breath and healing)
The Human Connectome Project
Previous episode with Dr Yeoh on mitochondria
Resourses:
Next Practice Genbiome, Sydney (genbiome.nextpracticehealth.com)
Mitocore, Sydney (mitocore.com.au)
This episode is for general education and isn't personal medical advice. Speak with a qualified practitioner before changing your health routine or starting supplements.
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