NEJM This Week — October 16, 2025

This week, we explore new evidence comparing oral anticoagulants for acute venous thromboembolism, treatment for chemotherapy-induced thrombocytopenia, and early results of gene therapy for inherited deafness. We also examine evolving strategies for chronic lymphocytic leukemia, ... Show More

This week, we explore a phase 3 trial of finerenone in type 1 diabetes and chronic kidney disease and guidance on timing of nonculprit-lesion PCI after STEMI. We cover an investigational therapy for Dravet syndrome and neoadjuvant treatment for high-risk intrahepatic cholangiocar ... Show More

This week, we explore a new standard of care for high-risk HER2-positive early breast cancer, long-acting therapy for people with HIV facing adherence challenges, a first-in-class trial of a p53 reactivator, and tecovirimat for mpox. We review group B streptococcal disease and a ... Show More

Trials of a cancer 'vaccine' have begun and presenter James meets Steve, one of the first patients to trial the new treatment, Steve remembers his shock at being diagnosed with colorectal cancer in his 40s and tells the story of how he became involved in this pioneering research ... Show More

For the past few months, measles has been in regular rotation in the news cycle here in the US, with outbreaks occurring across the country in regions with low vaccine uptake. These outbreaks represent a worrying trend in the rejection of scientific and medical expertise, with lo ... Show More

Drs Michael S. Saag and David H. Spach discuss HIV and the nuances of primary care treatment, with a special focus on vaccines, including COVID, hepatitis, varicella zoster virus, and mpox. Relevant disclosures can be found with the episode show notes on Medscape (https://www.med ... Show More

En 2023, l’OMS et l’Unicef constataient une stagnation de la couverture vaccinale infantile dans le monde, entraînant une recrudescence de certaines maladies, comme la rougeole. Pourtant, les jeunes enfants sont davantage exposés aux risques de complications de ces maladies, la m ... Show More

In this podcast, Dr. Anne Connolly discussed endometrial and cervical cancers, with a focus on early diagnosis. The podcast covers the different risk factors for the two cancers and how knowledge of these risk factors can help with diagnosis and prevention. As part of this the ce ... Show More

What every ENT needs to know about the resurgence of measles—and how to talk to patients about vaccines. In this episode of the Back Table ENT podcast, Dr. Romaine Johnson and Dr. Daniel Chelius, both pediatric otolaryngologists, talk about the resurgence of measles and vaccine h ... Show More

Kieran Walsh, clinical director at BMJ, asks editors from BMJ Learning and BMJ Best Practice to summarise the latest clinical guidance related to covid-19. Matt Castleden updates us on the clinical use of antibody testing. And Abigail Davis discusses the impact of the pandemic on ... Show More

Approaches used to target particularly tricky diseases to treat, such as malaria, HIV, Flu and TB. Whilst many of the world’s major diseases can be targeted by vaccines there is a drastic need for new or improved vaccines against a number of the most deadly including HIV, malaria ... Show More

Measles is a serious disease. Unfortunately, it is making a comeback. So we need to know how to diagnose, manage and prevent it. To find out more about how to do all of this, listen to this BMJ Best Practice podcast interview with Linda Nield, Professor of Medical Education and P ... Show More