Ready to learn about the secret compounds, molecules, nootropics, and stacks that Big Pharma doesn’t want you to know about? This episode is packed with the exact dopamine-boosting compounds, stacks, and biohacking protocols that top performers are using to supercharge human performance, brain optimization, and long-term resilience.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Lucas Aoun, Australia’s leading biohacker and founder of Ergogenic Health. Known for his fearless, data-driven experimentation, Lucas specializes in nootropics, dopamine modulation, mitochondria, and functional medicine. He’s spent over a decade testing underground compounds, natural molecules, and hormone-based strategies to achieve elite-level brain and body performance.
Together, they explore Russian-developed enhancers like Bromantane and ITPP, and reveal how these rare compounds impact dopamine regulation, neuroplasticity, and mental drive. You’ll learn how to upregulate tyrosine hydroxylase (your brain’s dopamine switch), build targeted stacks for motivation and confidence, and avoid the common supplements that quietly kill your ambition.
They also dive into the connection between dopamine and testosterone, explaining how to rewire hormonal feedback loops to reclaim masculinity, energy, and purpose. From libido hacks and prolactin suppression to stacking dopamine with GABA and acetylcholine, this episode gives you a complete system for motivation mastery.
Other key topics include the dangers of chronic ashwagandha use, sleep optimization for dopamine recovery, the truth about adaptogens and cold therapy, ketosis, fasting, DHT science, ciproheptadine microdosing, and why mitochondrial support is essential for long-term performance and metabolism.
You’ll Learn:
• The #1 Russian compound for explosive dopamine and drive
• Why most “calming” supplements destroy your ambition
• How dopamine and DHT shape masculinity and performance
• Advanced biohacks for sleep, motivation, libido, and mood
• The truth about serotonin dominance and how to escape it
• Which functional medicine tools enhance brain energy and metabolism
• How to build your own dopamine protocol using proven nootropics
• Why mitochondrial health is the hidden key to motivation and mood
This is essential listening for anyone serious about biohacking, brain optimization, hormone hacking, nootropics, functional medicine, emotional resilience, and building a state of unstoppable energy.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
Thank you to our sponsors!
Resources:
• Lucas’s Website: https://www.boostyourbiology.com/
• Lucas’s YouTube: https://www.youtube.com/c/boostyourbiology
• Dave Asprey’s Website: https://daveasprey.com
• Danger Coffee: https://dangercoffee.com/DAVE15
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Upgrade Collective: https://www.ourupgradecollective.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen: https://40yearsofzen.com
Tags:
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