Asenapine is an atypical antipsychotic that acts as an antagonist at multiple receptors, including dopamine D2 and serotonin 5-HT2A, contributing to its antipsychotic and mood-stabilizing effects.
Adverse effects of asenapine include somnolence, dizziness, and extrapyramidal symptoms.
Because asenapine is significantly metabolized by CYP1A2, inhibitors ... Show More
Aug 7
Itraconazole Pharmacology
In this episode, we break down itraconazole—a potent antifungal with a lot of baggage. If you’re a pharmacist, clinician, or student who needs to understand how this drug works and why it can be tricky to use, this episode is for you. We start with the basics. Itraconazole blocks ... Show More
10m 50s
Aug 2023
Increasing Dopamine: The Key to Focus, Motivation, and Happiness
The episode focuses on increasing dopamine, a neurotransmitter involved in focus, motivation, reward, pleasure, and happiness. Nurse Doza recommends taking vitamin B9, particularly the methylated form called 5MTHF, to support dopamine production. He explains that many people are ... Show More
30m 30s
Aug 2024
184 - Drop it Like it’s Hot! Deprescribing Pharmacotherapy When Appropriate
In this episode, we discuss the approach to deprescribing for several drugs such as benzodiazepine receptor agonists, cholinesterase inhibitors, memantine, antipsychotics, and antihyperglycemics. Key Concepts Medication appropriateness including indication and risk vs. benefit sh ... Show More
38m 50s
Feb 2025
410. Case Report: A Curious Case of Refractory Ventricular Tachycardia – Rutgers-Robert Wood Johnson
CardioNerds (Dr. Colin Blumenthal and Dr. Saahil Jumkhawala) join Dr. Rohan Ganti, Dr. Nikita Mishra, and Dr. Jorge Naranjo from the Rutgers – Robert Wood Johnson program for a college basketball game, as the buzz around campus is high. They discuss the following case involving a ... Show More
40m 13s