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Mar 2025
1h 51m

#099 The Science of Exercise for Cancer ...

RHONDA PATRICK, PH.D.
About this episode

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For decades, exercise was considered an optional part of cancer care—something beneficial for general health but not essential. The evidence is now overwhelming: exercise is not just supportive—it’s a therapeutic intervention that recalibrates tumor biology, enhances treatment tolerance, and improves survival outcomes.

With over 600 peer-reviewed studies, Dr. Kerry Courneya's work has fundamentally reshaped our understanding of how structured exercise—whether aerobic, resistance training, or high-intensity intervals—can mitigate treatment side effects, enhance immune function, and directly influence cancer progression.

Timestamps:

  • (00:00) Introduction
  • (04:31) Why exercise should be effortful
  • (05:17) How to meaningfully reduce risk of cancer
  • (09:06) What type of exercise is best?
  • (10:43) How exercise reduces risk—even for smokers and the obese
  • (13:32) Weekend-only exercise
  • (16:33) 150 vs. 300 minutes per week (more is better—up to a point)
  • (18:47) Why pre-diagnosis exercise matters
  • (21:53) Why resilience to cancer treatment starts with exercise
  • (23:45) Why low muscle mass drives cancer death
  • (26:42) Why BMI fails to measure true obesity
  • (30:35) Why daily activity isn't enough (structured exercise matters)
  • (32:18) Breaking up sedentary time—do 'exercise snacks' help?
  • (34:34) Supplements vs. exercise
  • (35:16) Where exercise fits with chemo and immunotherapy
  • (38:14) Why rest is not the best medicine
  • (44:04) Aerobic vs. resistance
  • (44:57) How weight training improves 'chemo completion'
  • (47:25) Why exercise creates vulnerability in cancer cells (limitations do apply)
  • (49:53) Why exercise might be crucial for tumor elimination
  • (55:47) Why cardio may be better at clearing tumor cells
  • (59:02) When cancer spreads quickly—and when it doesn't
  • (1:00:27) Why liquid biopsies may prevent over-treatment
  • (1:05:40) Exercise-sensitive vs. exercise-resistant cancers
  • (1:08:50) Prostate cancer therapy—why strength training matters
  • (1:10:54) When exercise is the only therapy—does it work?
  • (1:12:10) Why HIIT reduces PSA in prostate cancer
  • (1:14:24) Avoiding overtreatment—can exercise buy you time?
  • (1:14:44) Why high-intensity exercise boosts anti-cancer biology
  • (1:15:55) Turning a diagnosis into a wake-up call
  • (1:18:55) Why oncologists are rethinking exercise
  • (1:21:34) Why exercise eases anxiety about cancer—proven psychological benefits
  • (1:27:44) Before, during, and after treatment
  • (1:29:46) Why exercise is unique among cancer therapies
  • (1:31:00) Why cancer patients stop exercising—the risky mistake almost everyone makes
  • (1:33:25) How to get sedentary cancer patients exercising (realistically)
  • (1:35:59) The $1 million per patient case for including exercise
  • (1:37:40) Why recurrence trials haven't convinced doctors—yet
  • (1:40:20) The bottom-line message
  • (1:40:39) The myth of a cancer panacea (exercise included)
  • (1:46:51) What's the best $50 investment for staying active?
  • (1:47:24) Only 15 minutes per day—what's the best anti-cancer exercise?

Show notes are available by clicking here

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