The Future of Vaccines: An Interview with the Doctor Who Created the First Fully Humanized Immune Systems in Mice
Episode 49:
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Welcome to Pediatrics Now, hosted by Holly Wayment. In this episode, we are honored to have Dr. Paolo Casali from the University of Texas Health Science Center at San Antonio, a distinguished professor with groundbreaking research in immunology. Dr. Casali and his team have developed the first fully humanized immune system in mice, a monumental achievement that could revolutionize medicine for years to come.
Dr. Casali explains the detailed process of creating these humanized mice, which involves grafting human hematopoietic stem cells into immunodeficient mice, resulting in a fully functional human immune system. He shares the significance of this breakthrough, including its potential impact on vaccine development, drug testing, and cancer therapies.
Through engaging discussions, Dr. Casali highlights the challenges and triumphs of his research journey, offering listeners an inspiring glimpse into the future of medical science. Tune in to understand how these humanized mice can pave the way for better vaccines and targeted therapies, ultimately reducing the need for animal testing and advancing human health.
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