•Only 30% of patients fully respond to the initial SSRI
•Ultimately less than 55% of people respond to any SSRI.
• WHY???
• SSRIs typically only work on the 5HTIA receptor, but multiple 5HT receptors are involved in mood regulation: 1, 2,
• SSRIs only impact one area of possible dysfunction
• Serotonin creation, secretion, absorption, distribution is impacted by multiple factors.
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