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Jan 2024
39m 30s

Depression und Antidepressiva: Fragliche...

AMBOSS-Redaktion
About this episode
mit Britta Verlinden und Philipp Winghart

Monoaminmangelhypothese: Studienlage und alternative Erklärungsmodelle

Inhaltsverzeichnis: 00:00 Intro 02:59 Die Monoaminmangelhypothese 06:58 Grenzen der Hypothese 10:38 Depression ist nicht gleich Depression 16:48 Die Monoaminrezeptorhypothese 19:25 Nebennierenrinde, Cortisol, Hippocampus: die „Teufelskreis-Hypothese“ 23:08 Stress und Auswirkung auf die Neuroplastizität 28:33 Wirken Antidepressiva über den Placeboeffekt hinaus? 31:06 Exkurs: Publication Bias 34:17 Debatte über Studienlimitationen 36:16 Folgen für die ärztliche Praxis

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Quellen:

Hirschfeld RM. History and evolution of the monoamine hypothesis of depression. J Clin Psychiatry. 2000;61 Suppl 6:4-6.

Pilkington PD, Reavley NJ, Jorm AF. The Australian public’s beliefs about the causes of depression: associated factors and changes over 16 years. J Affect Disord. 2013;150:356–62.

Read J, Renton J, Harrop C, Geekie J, Dowrick C. A survey of UK general practitioners about depression, antidepressants and withdrawal: implementing the 2019 Public Health England report. Therapeutic Advances in. Psychopharmacology.

Ruhé, H. G., Visser, A. K. D., Frokjaer, V. G., Haarman, B. C. M., Klein, H. C., and Booij, J. (2014). “Molecular imaging of depressive disorders,” in PET and SPECT in Psychiatry, eds R. A. J. O. Dierckx, A. Otte, E. F. J. de Vries, A. van Waarde, and J. A. den Boer (Berlin, Heidelberg: Springer), 93–172.

Ruhé, H. G., Mason, N. S., and Schene, A. H. (2007). Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol. Psychiatry 12, 331–359. doi: 10.1038/sj.mp.4001949

Binder, E. B., and Nemeroff, C. B. (2010). The CRF system, stress, depression and anxiety—insights from human genetic studies. Mol. Psychiatry 15, 574–588. doi: 10.1038/mp.2009.141

Holsboer, F., and Barden, N. (1996). Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr. Rev. 17, 187–205. doi: 10.1210/er.17.2.187

Pittenger, C., and Duman, R. S. (2008). Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 33, 88–109. doi: 10.1038/sj.npp.1301574

Carlezon, W. A. Jr., Duman, R. S., and Nestler, E. J. (2005). The many faces of CREB. Trends Neurosci. 28, 436–445. doi: 10.1016/j.tins.2005.06.005

Kirsch I, Sapirstein G. Listening to prozac but hearing placebo: A meta-analysis of antidepressant medication. Prev Treatm 1998; 1(1).

Turner EH, Matthews AM, Linardatos E, et al. Selective publication of antidepressant trials and its influence on apparent efficacy. N. Engl. J Med 2008; 358(3):252–60. http://www.ncbi.nlm.nih.gov/pubmed/18199864.

Lacasse JR, Leo J. Serotonin and depression: a disconnect between the advertisements and the scientific literature. PLoS Med. 2005 Dec;2(12):e392. doi: 10.1371/journal.pmed.0020392. Epub 2005 Nov 8. PMID: 16268734; PMCID: PMC1277931.

Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT. Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS Med. 2008;5(2):e45. doi:10.1371/journal.pmed.0050045

Kirsch I. Antidepressants and the Placebo Effect. Z Psychol. 2014;222(3):128-134. doi: 10.1027/2151-2604/a000176. PMID: 25279271; PMCID: PMC4172306.

Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018;391(10128):1357-1366. doi:10.1016/S0140-6736(17)32802-7

Munkholm K, Paludan-Müller AS, Boesen K. Considering the methodological limitations in the evidence base of antidepressants for depression: a reanalysis of a network meta-analysis. BMJ Open. 2019;9(6):e024886. Published 2019 Jun 27. doi:10.1136/bmjopen-2018-024886

Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. The serotonin theory of depression: a systematic umbrella review of the evidence [published online ahead of print, 2022 Jul 20]. Mol Psychiatry. 2022;10.1038/s41380-022-01661-0. doi:10.1038/s41380-022-01661-0 trint

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