The Natural Experiment

One study from 2018 found that Major League Baseball umpires blow about 14 calls every game. That’s 34,000 bad calls every year. And it makes a difference. A blown strike call can decide a win or a loss, a championship or six months at home, wondering what could have been. And wh ... Show More

A missing car reveals the confusing rules, murky fees, and private actors behind modern towing. What infrastructure mystery keeps you up at night? Submit your Service Request by recording a voice memo with your question and emailing it to servicerequest@99pi.org. Service Request ... Show More

In a place where losing power can turn deadly, keeping the lights on is a high-stakes balancing act. What infrastructure mystery keeps you up at night? Submit your Service Request by recording a voice memo with your question and emailing it to servicerequest@99pi.org. Service Req ... Show More

Not all inventions are the product of careful experimentation. Sometimes, someone pulls a whoopsie and learns something new. This episode is all about those types of discoveries.See omnystudio.com/listener for privacy information. 

Natural viruses and bacteria can be deadly enough; the 1918 Spanish Flu killed 50 million people in four months. But risky new research, carried out in an unknown number of labs around the world, are creating even more dangerous humanmade pathogens. (Original score by Point Lobo. ... Show More

<p>In December 1988, two sets of identical twins became test subjects in a study for which they had never volunteered. It was an experiment that could never be performed in a lab, and had never before been documented. This week, we revisit this fascinating story, told by <a href= ... Show More

Until 2020 developing a new drug took at least 15 years. Scientists by and large competed with each other, were somewhat secretive about their research and only shared their data once publication was secured. And the public and the press had no interest in the various early phase ... Show More

00:46 Uncovering the origins of the Black DeathThe Black Death is estimated to have caused the deaths of up to 60% of the population of Europe. However, despite extensive research, the origin of this wave of disease has remained unclear. Now, by using a combination of techniques, ... Show More

Des nouvelles de la mort. Une récente étude internationale affirme en effet qu’après un arrêt cardiaque le passage de vie à trépas est loin d'être immédiat, et prend environ 10 minutes dans le cerveau. Durant ce laps de temps, qui nous sépare de l’extinction définitive du système ... Show More

Neuroscientists are creating more naturalistic experiments that they hope will provide a more nuanced understanding of animal — and human — behaviour.These set-ups differ from the classic laboratory experiments that have been used for decades, and may help in the understanding of ... Show More

Gene editing was a new idea in the mid-1970s. So when Harvard and MIT planned new research in recombinant DNA, alarm bells went off. "People were worried about a 'Frankengene,'" says Lydia Villa-Komaroff, then a freshly minted PhD. Amidst a political circus, the city of Cambridge ... Show More

Since the beginning of the pandemic, there have been allegations that SARS-CoV-2 could have originated in a Chinese lab. A phase one WHO investigation concluded that a 'lab-leak' was "extremely unlikely" and yet, the theory has seen a resurgence in recent weeks with several scien ... Show More