logo
episode-header-image
Dec 2022
11m 42s

From Scientific Exile To Gene Editing Pi...

NPR
About this episode
Gene editing was a new idea in the mid-1970s. So when Harvard and MIT planned new research in recombinant DNA, alarm bells went off. "People were worried about a 'Frankengene,'" says Lydia Villa-Komaroff, then a freshly minted PhD. Amidst a political circus, the city of Cambridge, Massachusetts banned research into recombinant DNA, forcing scientists like Villa-Komaroff into exile. But that turned out to be just the prelude to a breakthrough. In this episode, Dr. Villa-Komaroff tells Emily Kwong the story of overcoming the skeptics and coaxing bacteria into producing insulin for humans.

Learn more about sponsor message choices: podcastchoices.com/adchoices

NPR Privacy Policy
Up next
Yesterday
Doing Science at the Edge of the Earth
Some scientific discoveries take place in a lab. Others are made deep in the rainforest, along the ocean floor or on the dark side of the moon. And still others are made squelching through mud and ice on the northernmost island on Earth… at least, if you’re NPR climate correspond ... Show More
13m 15s
Oct 7
Solved: The Potato Origin Mystery
Usually, when two different species mate, it’s a disaster. At least, that’s what scientists had generally thought about hybrids, the offspring of these unions. But some researchers are starting to change their view as they learn of more beneficial hybrid events. The Atlantic scie ... Show More
12m 27s
Oct 6
The Science Of Fear And Horror Movies
Creepy crawly season is upon us, Short Wavers! We're welcoming fall with a contemplation of fear and anxiety. In human history, fear kept us safe. It helped us flee from predators. Anxiety made us wary of potential dangers — like venturing into a known lion-infested area. But wha ... Show More
13m 45s
Recommended Episodes
Mar 2023
Babbage: The hopes and fears of human genome editing
The Third International Summit on Human Genome Editing was held this week in London. It was the first such meeting since 2018, when a Chinese researcher announced that he had created the world’s first genetically edited babies—a move that was roundly condemned at the time. Host A ... Show More
45m 37s
May 2023
#77 — The Moral Complexity of Genetics
Sam Harris speaks with Siddhartha Mukherjee about the human desire to understand and manipulate heredity, the genius of Gregor Mendel, the ethics of altering our genes, the future of genetic medicine, patent issues in genetic research, and other topics. Siddhartha Mukherjee is a ... Show More
33m 16s
May 2023
70th anniversary of the discovery of DNA’s structure
James Watson and Francis Crick, who detailed the double-helix structure of DNA in 1953, are perhaps two of the most iconic scientists of the 20th Century. Yet the story of how they made their incredible discovery is perhaps equally famous, with a notorious narrative suggesting th ... Show More
32m 46s
Jul 2018
a16z Podcast: The Scientific Revolution of Ancient DNA
with Jorge Conde (@jorgecondebio), David Reich, and Hanne Tidnam (@omnivorousread) Trying to reconstruct the deep past of ancient humans out of present-day people has until now been like trying to reconstruct a bomb explosion in a room from bits of shrapnel, says David Reich, Pro ... Show More
31m 38s
Jan 2020
The silence of the genes
In summer of 2019 NICE approved the use of a completely new class of drugs: the gene silencers. These compounds are transforming the lives of families who have rare debilitating – and sometimes fatal - diseases such as amyloidosis and porphyria. James Gallagher, BBC Health and Sc ... Show More
27m 21s
Feb 2023
Bad Blood: Newgenics
Are we entering a ‘newgenic’ age - where cutting-edge technologies and the power of personal choice could achieve the kind of genetic perfection that 20th century eugenicists were after?In 2018, a Chinese scientist illegally attempted to precision edit the genome of two embryos. ... Show More
28m 18s