logo
episode-header-image
Sep 2019
15m 11s

A “living drug” that could change the wa...

TED
About this episode

Carl June is the pioneer behind CAR T-cell therapy: a groundbreaking cancer treatment that supercharges part of a patient's own immune system to attack and kill tumors. In a talk about a breakthrough, he shares how three decades of research culminated in a therapy that's eradicated cases of leukemia once thought to be incurable -- and explains how it could be used to fight other types of cancer.

Vote for our show in the Signal Awards for Most Inspirational podcast!


Hosted on Acast. See acast.com/privacy for more information.

Up next
Yesterday
The three words that saved my life | Blake Mycoskie
On paper, Blake Mycoskie is a glowing success story: he founded TOMS Shoes, building a global brand that has given away more than 100 million pairs of shoes to children in need. Yet despite his success, his struggle with depression nearly cost him his life. In this personal talk, ... Show More
18m 48s
Oct 8
How imaginary worlds help kids learn | Anna Rainio
All children develop at different paces — so why do schools expect every student to learn the same way? Early education researcher Anna Rainio introduces "playworlds," a learning activity where adults and kids create imaginary stories together. She shows how pretend play helps st ... Show More
17m 42s
Oct 7
What my politically divided family teaches me | Tami Pyfer
Tami Pyfer has five kids who belong to five different political parties, and sometimes family conversations get heated. Drawing on her work as a former policy advisor to the governor of Utah, she wanted to find a healthier way for people to talk about politics without contempt. T ... Show More
14m 3s
Recommended Episodes
Sep 2023
Unleashing CAR T with Carl June
<p>Carl June, MD, an immunologist and oncologist at the University of Pennsylvania, joins Jorge Conde, general partner at a16z Bio + Health.</p><p>Together, Carl and Jorge talked about Carl's pioneering work in CAR T therapy — including the terrifying moment where he thought he h ... Show More
27m 49s
Jun 2023
Unleashing CRISPR on Cancer
In this episode of “Intention to Treat,” host Rachel Gotbaum explores the story of a teenager who’s now in remission from previously relapsed lymphoblastic leukemia and talks with the investigator who developed the “off-the-shelf” CAR T cells that made her treatment possible. A f ... Show More
52m 50s
Nov 2024
CAR T Cells and T-Cell Therapies for Cancer
<p>CAR T cells are genetically engineered to express a receptor that recognizes and kills tumor cells. CAR T-cell products are now FDA approved for 6 hematologic malignancies. Author Jennifer N. Brudno, MD, National Cancer Institute, joins JAMA Deputy Editor Mary McGrae McDermott ... Show More
18m 22s
Jun 2025
Reprogramming Immunity: Unlocking CAR-NK Cells with Dr. Hind Rafei
<p>In this episode, Dr. Hind Rafei dives into the cutting-edge world of CAR-NK cell therapy and its potential to revolutionize cancer treatment. Unlike their T-cell counterparts, CAR-NK cells promise enhanced safety and innate tumor-killing ability. But what if their power could ... Show More
26m 51s
May 2021
Ep. 4: “Therapeutic T Cell Engineering” Featuring Drs. Carl June and Philipp Rommel
Guests: Dr. Carl June is the Richard W. Vague Professor in Immunology at the University of Pennsylvania, Director of the Center for Cellular Immunotherapies at the Perelman School of Medicine, and Director of the Parker Institute for Cancer Immunotherapy. Dr. Philipp Rommel is a ... Show More
1h 13m
Nov 2025
Liver cancer: discovering the next generation of therapy targets
For decades, the fight against cancer has focused on killing the tumour cell. We treated cancer like an isolated entity that needed to be destroyed – but what if we’ve been looking at the wrong target? In this episode, we delve into the critical insight that cancer is not just a ... Show More
24m 6s
Jan 2018
Immune 4: Putting the immunotherapy CAR T before the cancer
<p>The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" rel="noopener">Vincent Racaniello</a ... Show More
1h 23m
Sep 2020
Immunotherapy: Transforming How Cancers Are Treated
In this episode, Dr. Diane Reidy-Lagunes talks to medical oncologist and scientist Dr. Jedd Wolchok and cancer survivor Grace Dunn. Together, they help decode the emerging new defense against cancer: immunology. For more information or to ask a question, please visit MSKCC.org/po ... Show More
23m 44s
Mar 2024
India’s Breakthrough in Cancer Cure
<p>Thejna John is a happy woman. Last year, the relapse of an acute form of blood cancer despite a bone marrow transplant, had made her doctors give up all hope.</p> <p>In October, came a breakthrough. India approved the CAR T-Cell therapy, a revolutionary treatment for some form ... Show More
30m 1s
Oct 2025
Reengineering Hope: CAR-T Therapy for Multiple Sclerosis
CAR-T therapy, short for chimeric antigen receptor T-cell therapy, is already transforming treatment for blood cancers like lymphoma and leukemia and is now being tested in early trials for multiple sclerosis. In this approach, a person's own T cells (or sometimes donor T cells) ... Show More
44m 8s