Listener feedback, transcatheter tricuspid valve replacement, a new metabolic disease called CKM, the ARISE-FLUIDS Trial, the BIHCA trial, and temporal trends in ICD therapies are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Listener Feedback

LOSE-AF Trial https://jamanetwork.com/journals/jama/fullarticle/2849335
ARREST-AF Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2840225
POP-AF Trial https://doi.org/10.1093/eurheartj/ehaf689
PRAGUE-25 Trial https://www.jacc.org/doi/10.1016/j.jacc.2025.04.042

II Transcatheter Tricuspid Valve Replacement

TRISCEND Cost Study https://doi.org/10.1016/j.shj.2026.101049
TRISCEND II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2401918

III More Disease Creation – the CKM Syndrome

ACC/AHA Release First-Ever Guideline for CKM Syndrome https://www.medscape.com/viewarticle/acc-aha-release-first-ever-guideline-ckm-syndrome-2026a1000jbs

CKM Guideline in Circulation https://www.ahajournals.org/doi/10.1161/CIR.0000000000001447

IV Two Trials That Teach Important EBM Lessons

ARISE-FLUIDS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2516225
Dr Josh Farkas Post on X https://x.com/PulmCrit/status/2065064796270022845?s=20

V Bicarbonate for Inpatient Cardiac Arrest –The BIHCA trial

BIHCA Trial https://jamanetwork.com/journals/jama/fullarticle/2850405

VI The Decline of VT in Heart Failure

Trends and Outcomes in ICD Recipients: 15-Year Analysis https://doi.org/10.1093/europace/euag110
Declining Risk of Sudden Death in HF https://www.nejm.org/doi/full/10.1056/NEJMoa1609758

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