Dr. Linda Chu speaks with Dr. Kavitha Chinnaiyan and Dr. Jonathon Leipsic about why 2026 marks an inflection point for coronary CT, from AI-enabled plaque quantification to FFR-CT and evolving guideline support for CT-first evaluation of suspected coronary artery disease. They explore how advanced imaging tools are reshaping risk assessment, personalizing prevention and revascularization decisions, and strengthening collaboration between radiology and cardiology while highlighting the need for validation, standardization, and equitable access.