Name: How Urolithin A Drives Mitochondrial Renewal and Slows Immune Aging
Description: Dr. Joseph Mercola - Take Control of Your Health · Episode · 2026

As you age, your thymus produces fewer newly formed cells responsible for responding to unfamiliar pathogens, reducing your immune system's adaptability. This shift, combined with persistent inflammation, defines the core features of immune aging
Urolithin A, a postbiotic compound, stimulates mitochondrial renewal in aging immune cells. A recent study shows it can increase naïve-like T cells and strengthen immune surveillance in just four weeks of supplementation
Clinical findings show that urolithin A boosts mitochondrial renewal pathways, increases markers linked to mitochondrial biogenesis, and improves immune cell metabolism
Beyond immune health, studies reveal that urolithin A influences cancer pathways, enhances muscle strength and endurance, improves fatty liver markers, and reshapes metabolic signaling involved in obesity and insulin resistance
Beyond using urolithin A, you can also support your mitochondria by lowering linoleic acid intake, eating the right carbohydrates, limiting environmental toxins, and supporting NAD⁺ production with niacinamide

As you age, your thymus produces fewer newly formed cells responsible for responding to unfamiliar pathogens, reducing your immune system's adaptability. This shift, combined with persistent inflammation, defines the core features of immune aging
Urolithin A, a postbiotic compound, stimulates mitochondrial renewal in aging immune cells. A recent study shows it can increase naïve-like T cells and strengthen immune surveillance in just four weeks of supplementation
Clinical findings show that urolithin A boosts mitochondrial renewal pathways, increases markers linked to mitochondrial biogenesis, and improves immune cell metabolism
Beyond immune health, studies reveal that urolithin A influences cancer pathways, enhances muscle strength and endurance, improves fatty liver markers, and reshapes metabolic signaling involved in obesity and insulin resistance
Beyond using urolithin A, you can also support your mitochondria by lowering linoleic acid intake, eating the right carbohydrates, limiting environmental toxins, and supporting NAD⁺ production with niacinamide

How Urolithin A Drives Mitochondrial Ren...