My guest is Dr. David Fajgenbaum, MD, professor of translational medicine and human genetics at the University of Pennsylvania. He explains how, unbeknownst to most doctors, many approved medications can successfully treat or even cure diseases other than the ones they are typically used to treat. He shares his story of escaping death from Castleman's diseas ... Show More
Jul 30
Essentials: How to Become Resilient, Forge Your Identity & Lead Others | Jocko Willink
In this Huberman Lab Essentials episode, my guest is Jocko Willink, a retired U.S. Navy SEAL officer, author and host of the Jocko Podcast. We discuss why discipline, rather than motivation, is the reliable driver of daily action, and how taking action is the most effective way t ... Show More
37m 12s
Jul 27
Your Top Health Questions Answered
I answer questions submitted by listeners about topics ranging from how to ensure great sleep after nighttime exercise, effective no-caffeine pre-workouts (that also improve your sleep quality), neuroscience-supported tools for improving your memory and sense of smell, nutrition ... Show More
1h 44m
Jul 23
Essentials: Using Meditation to Focus, View Consciousness & Expand Your Mind | Dr. Sam Harris
In this Huberman Lab Essentials episode, my guest is Dr. Sam Harris, PhD, a neuroscientist, bestselling author, and world-renowned meditation teacher whose work focuses on consciousness, ethics, and religion. We discuss how meditation can help us better understand the nature of t ... Show More
41m 4s
Sep 2025
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?
Dr. David Fajgenbaum, MD, MBA, MSc, is a pioneering physician-scientist, tenured professor at the Perelman School of Medicine at the University of Pennsylvania, and national bestselling author who transformed his personal battle with the rare, deadly Castleman disease into a glob ... Show More
1h 41m
Jul 2024
Case #17: Every Cure Pt.1 (Dr. David Fajgenbaum)
<p>Dr. David Fajgenbaum, once a college quarterback and competitive weightlifter, turned medical researcher, was the picture of health until he became critically ill at the age of 25. After all available treatments failed to keep him out of the ICU, David, with his friend Grant&r ... Show More
40m 48s
Aug 2025
The Medical Matchmaking Machine
<p>As he finished his medical school exam, David Fajgenbaum felt off. He walked down to the ER and checked himself in. Soon he was in the ICU with multiple organ failure. The only drug for his condition didn’t work. He had months to live, if that. If he was going to survive, ... Show More
1h 1m
Sep 2020
Chasing My Cure | Dr. David Fajgenbaum
<p>As a kid, all David Fajgenbaum could think about was football. It consumed his life, being the quarterback on a top college team was his singular mission. And, he accomplished that, landing a spot on Georgetown’s team. But, fate would soon step in, when the loss of his mom to ... Show More
1h 1m