Statin Myopathy

Guest: Stephen Kopecky, M.D.

Host: Sharonne Hayes, M.D.

Statins are very helpful to lower LDL cholesterol and subsequently lower cardiovascular risk. Studies of statins have excluded subjects that are statin intolerant which is usually due to muscle symptoms such as aches, called myalgias, muscle cramps, or weakness. One of the most significant predictors of statin intolerance is the dose -the higher the dose, the more likely to develop intolerance. Accepted in recommended ways to minimize intolerance is to use generic combination therapy with a lower dose statin and a cholesterol absorption inhibiting agent such as ezetimibe. Newer agents such as PCS K 9 inhibitors and inclisiran, both given subQ, and bempedoic acid may reduce statin muscle symptoms.

Topics Discussed:

Is any statin more or less likely to cause statin associated muscle symptoms?
Are there any protective medications that can minimize statin myalgias?
What newer non-statin agents have been shown to reduce risk of myalgias?
How is treating high cholesterol levels becoming more like treating blood pressure?

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Podcast episode transcript found here.