This Gene’s a Real MTHFR—Here’s What It’...

This Gene’s a Real MTHFR—Here’s What It’s Doing to Your Body This episode unpacks the powerful effects of the MTHFR gene mutation—on your heart, liver, brain, and mood. Learn how this tiny genetic hiccup can impact energy, detox pathways, mental health, and longevity—and what to do if you’ve got it.

1. Heart Disease Connection – MTHFR mutations elevate homocysteine, increasing risk for arterial inflammation, stroke, and dementia.
2. Liver Strain – MTHFR dysfunction contributes to fatty liver and reduces the body’s ability to detox.
3. Glutathione Production – The gene impacts your ability to make antioxidants like glutathione and NAC, which protect against oxidative stress.
4. Mood & Mental Health – MTHFR affects neurotransmitter production, especially serotonin and dopamine, increasing risk of depression and ADHD.
5. You Need Methyl Donors – Supplements like methylfolate, P-5-P, SAMe, and betaine are crucial to bypass genetic bottlenecks and restore methylation function.

Bliss, featuring SAMe and betaine (trimethylglycine), supports healthy methylation by donating methyl groups—essential for mood, energy, and detox. With sublingual delivery for rapid absorption, Bliss is ideal for those with MTHFR mutations needing extra support for neurotransmitter production, glutathione synthesis, and liver detox. A must-have if you struggle with low mood, brain fog, or inflammation.

Get it here: https://www.mswnutrition.com/products/bliss

00:00 START – Welcome to the School of Doza 01:00 – Introducing the MTHFR gene and its reputation 02:00 – Genetic testing and what a consult reveals 03:00 – Homocysteine, inflammation, and heart disease 05:00 – Nitric oxide, artery stiffness, and dementia risk 07:00 – Why everyone should test for MTHFR and homocysteine 08:00 – The liver’s overlooked connection to MTHFR 09:30 – How inflammation triggers liver enzymes 11:00 – Why even "normal" genes need lifestyle support 12:00 – Folate (B9) deficiency and its link to depression 13:30 – Personal story: low folate, high homocysteine, and recovery 14:30 – MTHFR, liver enzymes, and antioxidant production 16:00 – Glutathione and NAC: made in the liver, suppressed by MTHFR 18:00 – Methylation, DNA repair, and cancer risk 20:00 – GGT as a liver marker for oxidative stress 21:00 – Neurotransmitters and the B vitamins behind serotonin 22:00 – MTHFR, ADHD, and mental health 23:00 – How Bliss supports brain function and neurotransmitters 25:00 – Methyl donors vs. methylated B12 shots 26:30 – Why Bliss works better for many than other B complexes 27:00 – Research on betaine and SAMe: brain, mood, addiction 30:00 – Methylation and NAD, COMT, and why Bliss helps both 32:00 – Final thoughts: lifestyle can suppress even a “normal” gene

1. MTHFR Overview: https://www.ncbi.nlm.nih.gov/books/NBK66131/
2. Homocysteine and Heart Disease: https://pmc.ncbi.nlm.nih.gov/articles/PMC12027316/
3. GGT, Liver, and Glutathione: https://pmc.ncbi.nlm.nih.gov/articles/PMC2696075/
4. Antioxidants and Diabetes Risk: https://pubmed.ncbi.nlm.nih.gov/39442756/
5. Neurotransmitters and Depression: https://pmc.ncbi.nlm.nih.gov/articles/PMC4750636/
6. Methyl Donors and Mental Health: https://pmc.ncbi.nlm.nih.gov/articles/PMC10556504/
7. Betaine for Addiction and Mood: https://www.sciencedirect.com/science/article/abs/pii/S0278584624001611

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