Loxapine is a first-generation (typical) antipsychotic with dopamine D2 receptor antagonism as its primary mechanism, though it also has affinity for serotonin 5-HT2A receptors, making its pharmacology somewhat atypical.
Loxapine is available in multiple formulations, including oral capsules and an inhalation powder, the latter approved specifically for a ... Show More
Sep 25
Piperacillin/Tazobactam Pharmacology
Zosyn (piperacillin/tazobactam) is a broad-spectrum β-lactam/β-lactamase inhibitor combination used widely in hospitals. Piperacillin covers gram-positive, gram-negative, and anaerobic bacteria, while tazobactam helps protect against β-lactamase breakdown. It is commonly used for ... Show More
13m 18s
Aug 2024
184 - Drop it Like it’s Hot! Deprescribing Pharmacotherapy When Appropriate
In this episode, we discuss the approach to deprescribing for several drugs such as benzodiazepine receptor agonists, cholinesterase inhibitors, memantine, antipsychotics, and antihyperglycemics. Key Concepts Medication appropriateness including indication and risk vs. benefit sh ... Show More
38m 50s
Jul 23
192 - Opioids Optional: Journavx, the New Acute Pain Management Alternative
In this episode, we discuss the evidence, safety, and place in therapy of Journavx® (suzetrigine), a newly approved analgesic with a unique non-opioid mechanism of action and additional considerations for its use. Key Concepts Suzetrigine is a first in its class NaV1.8 sodium cha ... Show More
33m 57s
Feb 2025
410. Case Report: A Curious Case of Refractory Ventricular Tachycardia – Rutgers-Robert Wood Johnson
CardioNerds (Dr. Colin Blumenthal and Dr. Saahil Jumkhawala) join Dr. Rohan Ganti, Dr. Nikita Mishra, and Dr. Jorge Naranjo from the Rutgers – Robert Wood Johnson program for a college basketball game, as the buzz around campus is high. They discuss the following case involving a ... Show More
40m 13s
Sep 2024
Episode 200: Immune Checkpoint Inhibitors
We discuss a new class of medications, Immune Checkpoint Inhibitors, and their side effects. Hosts:
Avir Mitra, MD
Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Immune_Checkpoint_Inhibitors.mp3 Download Leave a Comment Tags: Oncology Show Notes Ov ... Show More
13m 26s