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Jun 2025
48m 49s

#103 A Deep Dive on Using Coffee For Hea...

RHONDA PATRICK, PH.D.
About this episode

Get access to more than 120 episodes of my premium podcast, The Aliquot, as a FoundMyFitness Premium Member

Coffee is one of the most powerful longevity tools we have, potentially reducing epigenetic age by up to one year in regular coffee drinkers, but its effectiveness hinges entirely on how you brew it. In this episode, I outline precisely how coffee reduces DNA damage, a key driver of cancer and cellular aging, and why choosing filtered coffee over methods like French press significantly lowers cholesterol risk. I’ll discuss exactly which beans and roasts pack the highest antioxidant punch, plus a practical tip on a specific supplement that amplifies coffee’s cognitive benefits. You’ll also learn the truth about mycotoxins in coffee and why adding dairy can blunt coffee’s immediate cognitive-boosting effects.

Timestamps:

  • (00:00) Introduction
  • (01:24) Can coffee really slow biological aging?
  • (04:42) Is coffee actually protective for your heart?
  • (05:27) Why morning coffee is healthier than afternoon coffee
  • (08:01) How coffee improves your metabolic health
  • (09:52) Can coffee reduce cancer risk?
  • (11:25) Does coffee protect DNA from damage?
  • (13:38) Can coffee enhance your gut microbiome?
  • (16:01) Can unfiltered coffee raise your cholesterol?
  • (20:13) Which brewing method maximizes antioxidants?
  • (20:40) Arabica or robusta—does bean type matter?
  • (23:04) Dark vs. light roast—what’s richer in antioxidants?
  • (23:28) Is cold brew coffee as healthy as hot coffee?
  • (23:51) Practical tips to maximize antioxidants
  • (24:38) Filtered vs. French press—what’s best for longevity?
  • (26:48) Can espresso’s antioxidants offset its cholesterol risk?
  • (27:18) Instant coffee—an overlooked longevity booster?
  • (27:40) Why filtered coffee is the clear winner
  • (28:20) Caffeinated vs. decaf—what’s better for your brain?
  • (30:42) Can decaf coffee still enhance cognitive function?
  • (33:38) How much caffeine is optimal for athletic performance?
  • (36:31) How decaffeination methods affect coffee’s benefits
  • (39:02) Are mold toxins in coffee really a concern?
  • (41:45) Is adding dairy a mistake?
  • (43:15) Does MCT powder boost cognition—or just cholesterol?
  • (44:59) Does adding L-theanine reduce caffeine-induced anxiety?
  • (47:04) The science-backed coffee routine for longevity

Show notes, transcript, and summary are available by clicking here

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