logo
episode-header-image
Jul 14
17m 21s

#356 - AMA #73: Preserving brain health,...

Peter Attia, MD
About this episode

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

In this “Ask Me Anything” (AMA) episode, Peter addresses frequently requested topics, including brain health, exercise programming, and body composition. He explores the factors that influence dementia risk—including metabolic health, fitness, sleep, hearing, cholesterol levels, and more. He explains how to implement zone 2 training and VO₂ max intervals for cardiovascular fitness and also covers how to combine cardio modalities, how to stay in zone 2, and special considerations for women. Peter highlights the benefits of light movement after meals and offers strength training tips for those managing injuries. Additional insights include how to maintain fat loss, the truth about so-called “slow metabolisms,” and how to set appropriate daily protein goals while managing the trade-off between lean mass and body fat over time.

If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #73 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

  • Overview of episode topics on brain health, cardiovascular training strategies, and body composition [2:15];
  • Understanding dementia risk: modifiable vs. non-modifiable contributors to cognitive decline [5:00];
  • The causality between metabolic health and dementia [9:45];
  • How diet and exercise influence brain health: energy balance and exercise as key preventative tools [13:30];
  • Why combining aerobic, resistance, and cognitively engaging activities offers the most comprehensive benefits for preventing cognitive decline [17:00];
  • Additional lifestyle factors that influence dementia risk: smoking, head trauma, alcohol, and sleep [19:45];
  • The link between hearing loss and dementia: dose-dependent risk and the case for correction [25:15];
  • How poor oral hygiene may contribute to neuroinflammation and dementia risk [27:30];
  • Supplements for brain health: which ones matter and when they’re worth considering [28:45];
  • Low LDL cholesterol and brain health: debunking the myth of cognitive risk [33:45];
  • How to approach zone 2 training: the importance of staying in zone 2 and tailoring intensity based on your time and goals [38:00];
  • Lactate testing for zone 2: clinical protocols and at-home approaches [43:00];
  • Combining modalities in zone 2 training: balancing enjoyment and efficiency [47:00];
  • Zone 2 training for women: addressing the misconception that zone 2 training is unnecessary or ineffective for postmenopausal women [49:30];
  • Effective strategies for VO₂ max training: short vs. long intervals [51:45];
  • The benefits of post-meal walking for glucose management, and why spikes in glucose during exercise aren’t harmful [56:45];
  • The role of stability training in supporting resistance work and healthy aging [1:00:15];
  • Adapting strength training to manage chronic back injuries and train for longevity [1:02:00];
  • The role of aerobic exercise (like zone 2) in fat loss, metabolic health, and weight maintenance [1:06:30];
  • Debunking the “fast vs. slow metabolism” myth: why energy balance and protein matter most for fat loss [1:09:45];
  • Lean mass vs. body fat: why both matter for health and longevity [1:12:15];
  • How protein intake impacts muscle mass and why pairing it with resistance training is significantly more effective [1:15:15]; and
  • More.

Connect With Peter on TwitterInstagramFacebook and YouTube

Up next
Oct 6
#367 - Tylenol, pregnancy, and autism: What recent studies show and how to interpret the data
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this special episode of The Drive, Peter addresses the recent headlines linking acetaminophen (Tylenol) use during pregnancy to autism in exposed ... Show More
1h 27m
Sep 29
#366 ‒ Transforming education with AI and an individualized, mastery-based education model | Joe Liemandt
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter Joe Liemandt is a software entrepreneur turned education reformer who left Stanford in 1989 to found Trilogy, a highly profitable private software c ... Show More
1h 47m
Sep 22
#365 ‒ Training for longevity: A roundtable on building strength, preventing injury, meeting protein needs, guidance for women and youth athletes, and more | Gabrielle Lyon, Mike Boyle, Jeff Cavaliere
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this special episode of The Drive, Peter hosts a strength and conditioning roundtable with three experts in the field—Gabrielle Lyon, Jeff Cavali ... Show More
2h 15m
Recommended Episodes
Sep 25
Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt
What if kids could master their academics in just two hours a day and spend the rest of their time developing real-world skills they’re passionate about? Joe Liemandt, founder of the software company Trilogy, is doing just that. Sarah Guo and Elad Gil are joined by Joe Liemandt, ... Show More
1h 1m
Feb 2025
How Generative AI is transforming L&D right now With Sean Bengry
As generative AI continues to evolve from novelty to everyday adoption, its transformative potential for Learning & Development is becoming increasingly clear. In this episode, Sean Bengry, a senior L&D leader, shares his experiences and insights on harnessing AI to drive impact ... Show More
49m 15s
Jul 2024
Leaning into A.I. with Jeff Utecht
Don't be afraid of the big, bad A.I.! In this episode, we sit down with educator, author, consultant and A.I. expert Jeff Utecht to dissect how AI tools like ChatGPT-4 have the potential to revolutionize the classroom. Utecht helps us navigate the delicate balance of excitement a ... Show More
33m 24s
Aug 2024
Flashback: Why Data is the New Code with Alexandr Wang of Scale AI
As a freshman at MIT, Alexandr was struck by his classmates' interest in AI. But he realized that despite all that AI technology could solve, there was no solution for managing AI-related data. So, at 19, he dropped out of college and started Scale AI. Scale now helps customers l ... Show More
34m 39s
Aug 16
#981 - MacKenzie Price - Alpha School: A New Approach To Education
MacKenzie Price is an entrepreneur, podcaster, and co-founder of Alpha Schools. Just how broken is education? For fifty years, lofty promises in education have yielded dismal results. Now, with AI, infinite knowledge at our fingertips, and personalized one-on-one learning, how ra ... Show More
1h 11m
Jan 2025
John Lee Reveals How AI Will Shape Your Wealth and Influence
🚨 In this episode of The Alpha Talks Show, we’re thrilled to welcome back John Lee, a globally recognized entrepreneur, investor, speaker, and mentor! 🚨Welcome back, Alpha Squad, to the #1 fastest-growing podcast in the region! Today, Seif El Hakim – The Alpha sits down with Jo ... Show More
1h 18m
Aug 2024
Simcenter HEEDS & Optimisation Problems - Justin Hodges | Podcast #125
Justin Hodges’ passion for Artificial Intelligence (AI) was ignited in 2017 during an internship at Siemens Healthineers, where he used computational fluid dynamics (CFD) to model airway diseases within the lungs. His experiments fusing AI with CFD tools and workflows produced as ... Show More
42m 5s
Jun 2024
Why AI Could Be the Best Teacher You Ever Have w/ Sal Khan
AI is accelerating at a dizzying pace and you’ve got to be prepared for what’s to come. It’s not a matter of if, but when… and it’s going to be sooner than you expect! In this electrifying episode, we’re discussing the boundless potential of artificial intelligence and its transf ... Show More
54m 18s
Aug 2024
How AI could save (not destroy) education | Sal Khan
Sal Khan, the founder and CEO of Khan Academy, thinks artificial intelligence could spark the greatest positive transformation education has ever seen. This week we're revisiting a talk where he shares the opportunities he sees for students and educators to collaborate with AI to ... Show More
15m 45s