Ketoconazole is an imidazole antifungal that works by inhibiting fungal cytochrome P450 14α-demethylase, an enzyme essential for ergosterol synthesis, which disrupts fungal cell membrane integrity.
Common adverse effects of ketoconazole include nausea, vomiting, abdominal pain, and elevated liver enzymes, with hepatotoxicity being a notable concern.
Ke ... Show More
Nov 20
Glycopyrrolate Pharmacology
Glycopyrrolate is an anticholinergic medication commonly used to reduce excessive secretions, particularly in palliative care, postoperative settings, and certain neurologic conditions. It works by blocking acetylcholine at muscarinic receptors, which decreases salivary and respi ... Show More
11m 47s
Nov 13
Bisacodyl (Dulcolax) Pharmacology
Bisacodyl, commonly known by the brand name Dulcolax, is a stimulant laxative widely used for short-term relief of constipation and bowel preparation before procedures. It works by directly stimulating the enteric nerves in the colon, increasing peristalsis, and promoting bowel e ... Show More
15m 53s
Mar 2025
Episode 948: CYP Inducers and Inhibitors
<p dir="ltr"><strong>Contributor: Jorge Chalit-Hernandez, OMS3</strong></p> <p dir="ltr">Educational Pearls:</p> <ul> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation">CYP enzymes are responsible for the metabolism of many medications, drugs, and other substances</p> ... Show More
3m 57s
Feb 2025
410. Case Report: A Curious Case of Refractory Ventricular Tachycardia – Rutgers-Robert Wood Johnson
CardioNerds (Dr. Colin Blumenthal and Dr. Saahil Jumkhawala) join Dr. Rohan Ganti, Dr. Nikita Mishra, and Dr. Jorge Naranjo from the Rutgers – Robert Wood Johnson program for a college basketball game, as the buzz around campus is high. They discuss the following case involving a ... Show More
40m 13s
Jan 2024
Supplement Ingredients: N-Acetyl-Cysteine (NAC) - A Versatile Supplement for Lung, Liver, and Brain Health
<p>This podcast discusses the benefits of N-Acetyl-Cysteine (NAC), a liver antioxidant that reduces inflammation in the body. NAC is a sulfur-based tripeptide that can detoxify the body and support liver health. It also serves as a precursor to glutathione, a master antioxidant. ... Show More
1m 56s
Jul 2025
192 - Opioids Optional: Journavx, the New Acute Pain Management Alternative
In this episode, we discuss the evidence, safety, and place in therapy of Journavx® (suzetrigine), a newly approved analgesic with a unique non-opioid mechanism of action and additional considerations for its use. Key Concepts Suzetrigine is a first in its class NaV1.8 sodium cha ... Show More
33m 57s
Sep 26
Advancing Real World Wound Care with Dr. Jaideep Banerjee of Smith+Nephew
<p>This episode features Dr. Jaideep Banerjee, Director of Global Clinical & Medical Affairs at Smith+Nephew, discussing the challenges of chronic wound care, the importance of standardized evidence-based practices, and insights from his recent large-scale study on enzymatic ... Show More
19m 35s
Dec 2023
Supplement Ingredients: Resveratrol - The Antioxidant in Red Wine
<p>The podcast discusses the benefits of resveratrol, a plant-based extract found in grapes, cacao, and peanuts. It is known for its antioxidant properties and has been shown to promote heart, liver, and brain health. Taking resveratrol daily can also help with blood sugar and in ... Show More
1m 56s