About this episode
Yesterday
Insights From the PVI-SHAM-AF
Catheter ablation is frequently performed to improve quality of life in patients with atrial fibrillation (AF). This randomized multicenter trial compared catheter ablation with a sham procedure to assess the true effect of the intervention on AF-related quality of life. In this ... Show More
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Impacts Of The FUND-HF Trial
The FUND-HF trial found that financial support provided soon after hospitalization is a practical strategy for improving medication adherence among economically vulnerable patients with heart failure and reduced ejection fraction. These results lay the groundwork for future trial ... Show More
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Primordial Prevention of CVD in Young
The future of cardiovascular health depends on prevention that begins early in life. This episode reviews strategies for recognizing cardiovascular risk at an early stage and implementing interventions that can alter the trajectory of atherosclerotic cardiovascular disease before ... Show More
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Jan 2025
409. Journal Club: The ARREST-AF Trial with Drs. Prashanthan Sanders and Mehak Dhande
Join CardioNerds EP Council Chair Dr. Naima Maqsood and Episode Lead Dr. Jeanne De Lavallaz as they discuss the results of the ARREST-AF Trial with expert faculty Dr. Prashanthan Sanders and Dr. Mehak Dhande. Audio editing by CardioNerds intern Bhavya Shah. The ARREST-AF trial en ... Show More
36m 4s
Oct 2025
The Lead Episode 121: A Discussion of Catheter Ablation or Antiarrhythmic Drugs for Ventricular Tachycardia, LIVE at HRX
Join Digital Education Committee host Jason Jacobson, MD, FHRS, as he discusses this late 2024 article with guests Miguel Valderrabano, MD, PhD, FHRS and J. Peter Weiss, MD, Msci, FHRS, from the HRSTv Studio in Atlanta at HRX 2025. The trial compared two treatment strategies for ... Show More
20m 32s
Apr 2023
Apr 21 2023 This Week in Cardiology
<p>John Mandrola, MD discusses early vs delayed AF ablation, a report on a devastating complication of AF ablation, and a potential crosswind for a major therapeutic fashion in electrophysiology.</p> <p><em>This podcast is intended for healthcare professionals only</em>.</p> <p>T ... Show More
28m 44s
Oct 2023
The Lead Podcast - Episode 31
<p class="p1"><span style="font-size: 10pt;">William H. Sauer, MD, FHRS, CCDS, of Brigham and Women's Hospital is joined by guests Thomas Tadros, MD, and Ashraf Sabe, MD, of Brigham and Women's Hospital, to discuss efficacy and safety of hybrid epicardial and endocardial ablation ... Show More
14m 41s
Oct 2022
#363 Afib: Rhythm Control, Catheter Ablation, Afib in the hospital, and Left Atrial Appendage Closure
Optimize and update your approach to atrial fibrillation (afib) as we discuss early rhythm control, antiarrhythmic drugs, TTE/cardioversion, afib ablation, new onset afib in the hospitalized patient, and left atrial appendage closure. Plus, we try to answer, Does afib burden matt ... Show More
53m 23s
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431. Atrial Fibrillation: Acute Management of Atrial Fibrillation with Dr. Jonathan Chrispin
Dr. Naima Maqsood, Dr. Kelly Arps, and Dr. Jake Roberts discuss the acute management of atrial fibrillation with guest expert Dr. Jonathan Chrispin. Episode audio was edited by CardioNerds Intern Dr. Bhavya Shah. This episode reviews acute management strategies for atrial fibrill ... Show More
37m 21s
Oct 2024
Atrial Fibrillation
<p>Following the European Society of Cardiology's (ESC) guidelines publication in collaboration with EACTS, Miia L Lehtinen and Can Gollmann-Tepeköylü host the esteemed Atrial Fibrillation experts, Manuel Castella and Niv Ad. In this month's episode, our guests explore the nuance ... Show More
29m 24s
Oct 2025
Oct 10 2025 This Week in Cardiology
GLP-1 use in HFrEF, left atrial posterior wall isolation during AF ablation, peri-device leaks for LAAO, new findings in post-cardiac surgery AF, and imaging before AF ablation are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for health ... Show More
26m 2s
Apr 2022
Podcast 773: Atrial Fibrillation Medications
3m 30s
Apr 2024
#150 Rhythm Control in Afib: 5 Pearls Segment
What are the benefits of early rhythm control versus rate control alone? When is electrical cardioversion used and what information can it tell us? What side effects for amiodarone, dofetilide, and sotalol, propafenone and flecainide? When should catheter ablation be considered i ... Show More
40m 8s
The PRAGUE-25 study evaluated the effectiveness of two treatment strategies in patients with both atrial fibrillation (AF) and obesity: catheter ablation versus lifestyle modification (including weight loss and increased physical activity) combined with antiarrhythmic drug therapy. While motivated patients who adhered to lifestyle changes experienced a reduction in AF episodes, the study found that catheter ablation was significantly more effective in achieving and maintaining sinus rhythm.
In this episode, Drs. Joseph Marine and Pavel Osmancik discuss the trial's findings, highlighting that catheter ablation outperformed lifestyle modification and medication in restoring and sustaining normal heart rhythm.
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Osmancik P, Havránek Š, Bulková V, et al. Catheter ablation versus antiarrhythmic drugs with risk factor modification for treatment of atrial fibrillation: a protocol of a randomised controlled trial (PRAGUE-25 trial). BMJ Open. 2022 Jun 15;12(6):e056522. doi: 10.1136/bmjopen-2021-056522.
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Pathak RK, Middeldorp ME, Meredith M, Mehta AB, Mahajan R, Wong CX, Twomey D, Elliott AD, Kalman JM, Abhayaratna WP, Lau DH, Sanders P. Long-Term Effect of Goal-Directed Weight Management in an Atrial Fibrillation Cohort: A Long-Term Follow-Up Study (LEGACY). J Am Coll Cardiol. 2015 May 26;65(20):2159-69. doi: 10.1016/j.jacc.2015.03.002.
<p><strong>Contributor: Aaron Lessen, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Atrial fibrillation is an irregular heart rhythm that sometimes requires rate control in setting of ... Show More
