Measurable residual disease and maintenance therapy in acute myeloid leukemia (AML), stemness and chemotherapy resistance in AML, and effects of babesiosis on red blood cells in sickle cell disease| Listen on Anghami

Jul 3

A novel mouse model of sickle cell SC disease; multiple myeloma induction therapy with isatuximab, carfilzomib, lenalidomide, and dexamethasone; and splicing factor mutations in myelodysplastic syndromes

In this week's episode we’ll learn more about a novel mouse model that recapitulates many of the properties of human sickle cell SC disease; results from the induction phase of the risk-adapted MIDAS trial of isatuximab, carfilzomib, lenalidomide, and dexamethasone in newly diagn ... Show More

19m 8s

Jun 26

An AI model for transplant risk in myelofibrosis; preventing priapism in men with sickle cell anemia; hallmarks of T cell exhaustion absent in newly diagnosed MM

In this week's episode, we'll learn about using AI to assess transplant risk in myelofibrosis. In a step toward personalized medicine, researchers report on a machine learning model that identifies 25% of patients with poor outcomes. After that: preventing priapism in men with si ... Show More

18m 24s

Jun 23

Social determinants of health and access to allogeneic hematopoietic cell transplantation, megakaryocyte growth factor receptor-based pretransplant conditioning for ex vivo autologous gene therapy, and novel protein biomarkers for risk stratification in a

In this week's episode, we’ll learn more about social determinants of health that impact access to allogeneic hematopoietic cell transplantation in patients with acute myeloid leukemia, or AML; use of megakaryocyte growth factor receptor-based stem cell depletion as part of pretr ... Show More

19m 38s

Feb 2025

Acute Leukemias

Ninja Nerds,Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Acute Leukemias, breaking down their pathophysiology, clinical presentation, and management. We explore the key differences between Acute Myeloid Leukemia (AML) and Acute Lymphobla ... Show More

45m 29s

Dec 2024

Allogeneic Stem Cell Donation

Allogeneic stem cell transplantation is a potentially life-saving therapy for some patients with hematologic and bone marrow cancers and certain nonmalignant conditions such as sickle cell disease. Hermioni L. Amonoo, MD, MPP, MPH, of Harvard Medical School and Dana-Farber Cancer ... Show More

14m 5s

Mar 2025

Lymphoma

Ninja Nerds,Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Lymphoma, breaking down its pathogenesis, clinical presentation, and the latest advancements in treatment. We explore the key differences between Hodgkin and Non-Hodgkin Lymphoma, ... Show More

34m 14s

Feb 2025

Ep 132: A 72-Year-Old with Fatigue and Dyspnea on Exertion

Today's patient is a woman who develops respiratory distress related to transfusion of red blood cells. Immunologic and non-immunologic complications of transfusion are discussed.See more on this topic on AccessMedicine.

9m 11s

Mar 2025

Myelodysplastic Syndrome (MDS)

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myelodysplastic Syndrome (MDS), a group of hematologic disorders characterized by ineffective hematopoiesis and a risk of progression to acute myeloid leukemia (AML). We also discuss the ... Show More

26m 35s

Nov 2024

Blood Transfusions

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive into blood transfusions, breaking down the essential components and clinical uses. We will discuss packed red blood cell transfusions (PRBC) for anemia management, platelet transfusions for ... Show More

1 h

Feb 2025

Plasma Cell Disorders

Ninja Nerds!Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we take a closer look at Plasma Cell Disorders, focusing on their pathophysiology, clinical features, and management. Topics include the mechanisms behind multiple myeloma, monoclonal gammopathy of ... Show More

27m 25s

Feb 2024

Is CRISPR the New Sickle Cell Savior?

2023 ended with an exciting biotech breakthrough for sickle cell patients. A gene-editing therapy using the revolutionary CRISPR technology provides new hope and options for the nearly 100,000 Americans with sickle cell disease. In this episode, we talk with the company behind on ... Show More

24m 39s

Feb 2025

Chronic Leukemias

Ninja Nerds,Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Chronic Leukemias, focusing on their pathogenesis, clinical features, and modern treatment strategies. We compare Chronic Myeloid Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL), di ... Show More

35m 23s

Measurable residual disease and maintena...