Allogeneic stem cell transplantation is a potentially life-saving therapy for some patients with hematologic and bone marrow cancers and certain nonmalignant conditions such as sickle cell disease. Hermioni L. Amonoo, MD, MPP, MPH, of Harvard Medical School and Dana-Farber Cancer Institute, joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the process of allogeneic stem cell donation. Related Content: