This week on The Genetics Podcast, Patrick is joined by Giles Yeo, geneticist and author of Gene Eating: The Science of Obesity and the Truth About Dieting and Why Calories Don't Count: How We Got the Science of Weight Loss Wrong. Giles and Patrick discuss the genetic, neural, and evolutionary drivers of obesity, the advancements in safe and effective obesity drugs, and the narratives around calorie counting and ultra-processed foods.
Show Notes:
0:00 Intro to The Genetics Podcast
00:59 Welcome to Giles and an overview of recent advances in obesity treatment
04:28 How incretin-based therapies such as GLP-1 receptor agonists have enhanced our understanding of obesity
06:46 Unexpected effects of GLP-1-based therapies on neurodegenerative disease and addiction
09:39 Relative safety and potential side effects of GLP-1-based therapies
11:18 The gap in genetic characterization of individuals with different responses to GLP-1-based treatment
13:10 Competition and demand in the market for obesity drugs
15:46 Targeting comorbidities and genetic and neural components of obesity
19:09 Evolutionary aspects of obesity and how modern world factors can increase risk
24:26 The role of choice in dietary habits
26:29 The spectrum of genetic influences on body weight
29:50 Next frontiers in obesity research and opportunities from genetic advances
32:52 The controversial premise of Giles’ second book on why calorie counting misses the point in improving diet and health
37:43 Giles’ nuanced perspective on ultra-processed foods
44:46 Future avenues for Giles’ research, including mapping genetics and neural circuits underlying obesity
46:05 Giles’ writing process and plans to write a third book
48:55 Closing remarks