logo
episode-header-image
Apr 2025
1h 34m

#479 Managing Treatment-Resistant Depres...

The Curbsiders Internal Medicine Podcast
About this episode
Lead the way in depression management! We’re joined by Dr. Jessi Gold, a psychiatrist and mental health advocate, who provides essential pearls on ways to recognize the multifaceted nature of depression and similarly presenting medical conditions. We also discuss the complexities of treatment options including various medication options and therapies, and how to choose between these treatments.

Claim CME for this episode at curbsiders.vcuhealth.org!

Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME

Show Segments

  • Intro
  • Case 1 from Kashlak
  • Medical conditions that can mimic depression
  • Diagnosis of depression
  • How to explain depression to family
  • Initial treatment options for depression
  • Case 2 from Kashlak
  • Suicide risk assessment
  • Trialing, augmenting, and tapering of medications
  • Pharmacogenetic testing
  • Alternate treatment options: TMS, ECT, ketamine, psilocybin, cannabis
  • Outro

Credits

  • Written and Produced by: Zoya Surani
  • Show Notes, Infographic, and Cover Art: Zoya Surani
  • Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP   
  • Reviewer: Sai Achi MD,MBA,FACP
  • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
  • Technical Production: PodPaste
  • Guest: Jessi Gold, MD

Disclosures

Dr. Gold reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures. 


Sponsor:
Panacea Financial 

Visit PanaceaFinancial.com to explore financial solutions designed to make your life better.

Sponsor:
FIGS

Go to WearFIGS.com and use the code FIGSRX to get 15% off your first order.

Sponsor:
Ezresus

Listeners of the Cribsiders get access to a 2-month free trial, letting them use 100% of the features of the app. For more information visit www.ezresus.com/curbsiders

Sponsor: Freed

Visit Freed.ai and use code CURB50 to get $50 off your first month when you subscribe!
Up next
Yesterday
Bonus: Hypermobility Q&A with Bendy Bodies Dr. Linda Bluestein
In this special bonus episode, Dr. Linda Blustein (Bendy Bodies https://bit.ly/m/BendyBodies) addresses listener questions about Ehlers-Danlos syndrome (EDS) and hypermobility spectrum disorders. 00:00 – Introduction 00:59 – Can PCPs diagnose hEDS without a geneticist? 03:19 – Li ... Show More
51m 22s
Aug 4
REBOOT: #452 NAFLD/MASLD with Dr. Elliot Tapper
We have a classic Curbsiders episode for you. Expert guest Dr. Elliot Tapper (@ebtapper) shares his framework for approaching NAFLD/MASLD and the treatment tools he recommends including lifestyle modifications and medications. 
1h 14m
Jul 28
#493: Joint Pain in Older Adults with Dr. Una Makris
An age-friendly approach to arthralgias. Attack arthralgias with ease! Learn how to evaluate and manage common joint complaints in older adults. We’re joined by Dr Una Makris, @unamakris.bsky.social (UT Southwestern). Claim CME for this episode at curbsiders.vcuhealth.org! Patreo ... Show More
1h 13m
Recommended Episodes
May 2024
Episode 104: Colorectal Cancer Series, Pt. 6 - Colorectal Cancer Pharmacology
We have another guest joining us this week! Dr. Allison Schepers, PharmD, BCOP is a Clinical Pharmacist Specialist at the Rogel Cancer Center at the University of Michigan where she focuses on GI, GU, and Thoracic malignancies! In this episode, Allison discusses the high yield po ... Show More
38m 36s
Mar 2025
163| Summary Scores – A Conversation With Dr. Andrew Kiselica
Today we give you our third conversation with Dr. Andrew Kiselica regarding aspects of neuropsychological test interpretation, with the current discussion focusing on summary scores. Show notes are available at www.NavNeuro.com/163 _________________ If you’d like to support the s ... Show More
13m 44s
Nov 2024
154| Long COVID – A Conversation With Dr. Lucette Cysique
This episode is a conversation with Dr. Lucette Cysique about long COVID. We discuss terminology, symptom profiles, epidemiology, biological mechanisms, psychological and sociocultural factors, overlap with chronic fatigue syndrome, overlap with functional neurological disorder, ... Show More
1h 33m
Jul 2024
Tanaz Danialifar - Carbs Causing Chaos: Disaccharidase Deficiencies
In this episode, hosts Drs. Peter Lu and Temara Hajjat talk to Dr. Tanaz Danialifar about diagnosing and treating disaccharidase deficiencies in children, including lactase deficiency and congenital sucrase-isomaltase deficiency (CSID).  Dr. Danialifar is a pediatric gastroentero ... Show More
56m 12s
Jul 2024
Episode 107: Colorectal Cancer Series, Pt. 9 - Metastatic Colorectal Cancer (Part 1)
This week, we continue our discussion of colorectal cancer, turning our attention to metastatic disease, specifically for cancers without targetable mutations. If you have not done already, we highly recommend you check out episode 104 for our GI oncology pharmacology discussion! ... Show More
34m 37s
Dec 2024
Immunization Updates 2024
Special guest Jean-Venable “Kelly” R. Goode, PharmD, BCPS, FAPhA, FCCP, Professor and Director of the Community-Based Residency Program at the Virginia Commonwealth University School of Pharmacy, join(s) us to talk about immunizations.Listen in as we discuss the latest COVID-19, ... Show More
36m 16s
Apr 2024
Precision Medicine in Follicular Lymphoma
Join us for this captivating interview with our guest Prof Stefano Luminari, MD, PhD, from the University of Modena and Reggio Emilia in Italy, as he explores what precision medicine means today for follicular lymphoma. Together with our host Dr. Isabel Olivera-Martinez, they dis ... Show More
19m 46s
Jul 2024
Episode 108: Colorectal Cancer Series, Pt. 10 - Metastatic Colorectal Cancer (Part 2)
This week, we round out our discussion on metastatic colorectal cancer, focusing on more targeted therapies for this disease. If you have not done so already, be sure to check out episode 107 for the first part of our metastatic colorectal cancer discussion.Contents: - What is th ... Show More
24m 34s
May 2024
Precision Medicine in Chronic Lymphocytic Leukemia (CLL)
Join us for a discussion with Prof Paolo Ghia, MD, PhD, from Università Vita Salute San Raffaele, Milan (Italy), as he explores how precision medicine is transforming CLL treatment. In this episode, discover how precision medicine is used daily in CLL to decide the best managemen ... Show More
21m 32s
Jul 2024
Dr Jessica Nolan - Lateropulsion
Dr Jess Nolan recently completed her PhD on Lateropulsion. Jess is a physio from Perth, Australia. Her credentials include BSc (Physio) - Curtin Uni, Grad Dip (Neuro Rehab) – UWA, member of ANZSO Emerging Stroke Clinician Scientist Committee, and Physio Working Party for the Stro ... Show More
1h 10m