In this inaugural episode of 'Talking Shift,' we dive deep into the complex world of managing refractory hypoxemia and ventilator settings with special guest Nick Ghionne, aka @PulmToilet. Explore strategies for optimizing ventilator parameters, understanding the role of driving pressure, effective use of PEEP, and the critical benefits of proning. We also discuss the nuanced use of adjuncts like nitric oxide and epoprostenol. Learn practical tips for real-life scenarios, ensuring better patient outcomes in critical care. Tune in to gain invaluable insights from two experts and elevate your critical care expertise!