Summary:
This week on The Genetics Podcast, Patrick is joined by Eric Adler, Chief Medical Officer and Head of Research at Lexeo Therapeutics and Professor of Medicine at University of California San Diego. Eric shares his experience with genetic cardiomyopathy and his work on gene therapy for Danon disease, drawing from both clinical and research perspectives. Additionally, he explores the evolution of the field and the broader challenges faced by cardiovascular patients.
Show Notes:
0:00 Intro to The Genetics Podcast
01:00 Welcome to Eric and his efforts in cardiomyopathy at the bench and bedside
03:32 How modeling genetic diseases using pluripotent stem cells lead Eric to studying Danon disease
04:50 Pivoting from basic to translational research using adeno-associated viruses (AAV)-based gene therapy
07:58 Uncovering genetic cardiomyopathies that were misdiagnosed as idiopathic cardiomyopathy
09:55 Treatment, screening, and penetrance of Danon disease
12:30 Recent successes and remaining challenges in cardiovascular disease
19:47 Battling distrust in the medical profession
21:55 Preventative therapy using APOE2 for patients at risk of early Alzheimer’s
25:15 Motivations behind and advantages of Eric’s patient-centered approach to therapeutics
27:24 Balancing regulatory requirements for protocols versus patient needs
29:49 The importance of committed clinical partners for successful trial execution
36:08 Eric’s passion for cooking and how he won a cooking competition
39:02 Closing remarks and Lexeo Therapeutics’ aims for 2025
Find out more
Lexeo Therapeutics (https://www.lexeotx.com/)
Please consider rating and reviewing us on your chosen podcast listening platform!
https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link