Today's patient is a woman who develops respiratory distress related to transfusion of red blood cells. Immunologic and non-immunologic complications of transfusion are discussed. See more on this topic on AccessMedicine. Harrison's Principles of Internal Medicine, 22nd Edition
Nov 2024
First-line asciminib for chronic myeloid leukemia, a new risk score for clonal cytopenia, and genotyped D-positive blood transfusion in sickle cell anemia
In this week's episode we’ll learn more about the ASCEND study, which investigated first-line asciminib in chronic phase chronic myeloid leukemia; a new risk score for myeloid neoplasm transformation in patients with clonal cytopenia of undetermined significance; and use of RHD g ... Show More
21m 19s
May 2025
Measurable residual disease and maintenance therapy in acute myeloid leukemia (AML), stemness and chemotherapy resistance in AML, and effects of babesiosis on red blood cells in sickle cell disease
In this week's episode, we’ll learn more about how measurable residual disease might help guide decisions about post-transplant gilteritinib maintenance in FLT3-ITD acute myeloid leukemia, or AML; how stemness contributes to chemotherapy resistance in AML; and effects of babesios ... Show More
19m 58s
Oct 2020
Updates in acute medicine: Pulmonary embolism and vaping associated lung injury
Kieran Walsh, clinical director at BMJ, asks Matt Castleden, GP and editor for BMJ Best Practice and BMJ Learning, to summarise the latest clinical guidance in acute medicine. Dr Castleden updates us on recent recommendations on pulmonary embolism, and also acute respiratory dist ... Show More
14m 31s
Oct 22
NEJM This Week — October 23, 2025
In this episode, we look at new research on mucoactive therapy for bronchiectasis, aspirin use in anticoagulated patients with coronary disease, and sotatercept for early pulmonary arterial hypertension. We explore the genetics behind misdiagnosed common diseases and review uncer ... Show More
25m 34s
Dec 2024
Primary resistance to BCMA-targeted bispecifics in multiple myeloma, emapalumab therapy in hemophagocytic lymphohistiocytosis, and chemotherapy-induced pyroptosis as a mechanism of thrombus formation
In this week's episode, we’ll learn more about mechanisms of primary resistance to BCMA-targeted bispecific T-cell engagers in relapsed/refractory multiple myeloma, the effects of emapalumab therapy on outcomes in patients with pediatric hemophagocytic lymphohistiocytosis who rec ... Show More
20m 5s
Nov 2021
Machine learning in classification of AML, aging bone marrow in leukemia, and treating bleeding disorders of unknown cause
In this week’s episode, we’ll learn more about the application of machine learning in molecular subclassification and prognostication of acute myeloid leukemia or AML, discuss the role of aging bone marrow in leukemia progression, and learn more about the challenges in treating b ... Show More
19m 25s