logo
episode-header-image
Feb 2025
23m 38s

Genetic testing for epilepsy surgery: Dr...

ILAE
About this episode

Send comments and feedback

In the second episode of our genetics and epilepsy series, Sharp Waves explores how genetic insights can inform considerations and outcomes of epilepsy surgery. Dr. Alina Ivaniuk interviews Dr. Patrick Moloney, currently an epilepsy genomics fellow at the Chalfont Center for Epilepsy at University College London.

Selected publications:
Do germline genetic variants influence surgical outcomes in drug-resistant epilepsy? Epilepsy Res 2024

Genomics in the presurgical epilepsy evaluation. Epilepsy Res 2022

Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice.

Let us know how we're doing: podcast@ilae.org.

The International League Against Epilepsy is the world's preeminent association of health professionals and scientists, working toward a world where no person's life is limited by epilepsy. Visit us on Facebook, Instagram, and LinkedIn.

Up next
Aug 18
Genetic testing: Variants of uncertain significance (VUS) - Dr. Gemma Carvill
Send comments and feedbackWhat are variants of uncertain significance (VUS) in epilepsy genetic testing? How are they defined, and can those definitions change over time? Sharp Waves talks with Dr. Gemma Carvill as part of our genetic testing series.RESOURCESStandards for interpr ... Show More
34m 22s
Aug 4
What's new in status epilepticus: Dr. Eugen Trinka
Send comments and feedbackThis episode covers a wide scope of issues, including treatment options, treatment response, prognosis and the role of seizures versus the underlying etiology, most common etiologies for different age groups, new-onset refractory status (NORSE), and the ... Show More
46m 4s
Jul 21
Valproate and reproductive risks in women and men with epilepsy: Dr. Tony Marson
Send comments and feedbackIn use since the 1970s, valproate is highly effective for genetic generalized epilepsies and some forms of pediatric epilepsy. The medication also is associated with a 10% risk of birth defects in children exposed to it in utero, as well as a 30% to 40% ... Show More
22m 28s
Recommended Episodes
May 29
Generalised seizures in adults
In 2016, the estimated number of people globally with active epilepsy was 45.9 million. For the US in 2015, this figure was around 3.4 million. So epilepsy is common and generalised seizures are a common type of epilepsy. And the consequences can be serious - from medication side ... Show More
28m 37s
Apr 2025
Episode 102: Pediatric Pulse Mini-Series: Inside the Epileptic Brain - How Myelin Plasticity Could Change Epilepsy Care
Pediatric epilepsy is a complex condition that affects countless children, but advancements in treatment are paving the way for brighter futures. Join us as Dr. Juliet Knowles, Assistant Professor of Neurology at Stanford University, sheds light on the multifaceted nature of epil ... Show More
25m 26s
Aug 18
Using Stem Cells to Cure Autism, Epilepsy & Schizophrenia | Dr. Sergiu Pașca
My guest is Dr. Sergiu Pașca, MD, professor of psychiatry and behavioral sciences at Stanford University. We discuss the biology and genetics of autism, why autism diagnoses are increasing and recent progress in using stem cells to understand and treat profound autism and other b ... Show More
2h 23m
Sep 2024
Neurological support post-cardiac arrest
Much attention has been paid to targeted temperature management (TTM) in post-cardiac arrest patients. The evidence for this practice continues to evolve, and previous episodes of Critical Matters have covered this topic. In this episode, Dr. Zanotti focuses on other aspects of N ... Show More
1h 12m
Apr 2024
Idiopathic Generalized Epilepsy - Part 3
In the third episode of this five-part series, Dr. Irfan Sheikh talks about Idiopathic generalized epilepsy. In this episode, he talks about juvenile absence epilepsy. 
2m 23s
May 7
Your Brain On... Brain-Computer Interfaces
Restoring a person’s ability to speak, enabling individuals with paralysis to regain movement, and detecting neurodegenerative diseases earlier than ever — these are just some of the breakthroughs brain-computer interfaces are making possible. In this episode, we explore the asto ... Show More
51m 37s
Jul 14
Ketones for Metabolic Health, Brain Function, & Fertility with Latt Mansor
Latt Mansor explores the multifaceted role of ketones, particularly their influence on brain health, fertility, memory, and focus. The re-release of an episode from 2023 delves into their impact on serotonin receptors, blood glucose regulation, and weight management. Mansor also ... Show More
1h 11m
Jul 14
Your Brain Is Suggestible. Here’s How To Turn That to Your Advantage. | Dr. Amir Raz
Harness the power of suggestion for well-being, pain management, and mental health. Dr. Amir Raz is a world-renowned expert on the science of suggestion with recent positions as Canada Research Chair, Professor of Psychiatry, Neurology and Neurosurgery, and Psychology at McGill U ... Show More
1h 12m
Jul 2024
Tanaz Danialifar - Carbs Causing Chaos: Disaccharidase Deficiencies
In this episode, hosts Drs. Peter Lu and Temara Hajjat talk to Dr. Tanaz Danialifar about diagnosing and treating disaccharidase deficiencies in children, including lactase deficiency and congenital sucrase-isomaltase deficiency (CSID).  Dr. Danialifar is a pediatric gastroentero ... Show More
56m 12s
Jul 2024
Your Brain On... Ozempic
Ozempic. Developed as diabetes medication. Adopted as a weight loss drug. Eyed for its potential neuroprotective effects. Hollywood’s popularization of Ozempic as a way to lose weight has made it one of the most widely-discussed drugs of our time, and has put immense stress on su ... Show More
33m 45s