logo
episode-header-image
Aug 2024
46m 6s

Your Brain On... Marijuana

Drs. Ayesha and Dean Sherzai
About this episode

The neuroscience behind the benefits and risks of marijuana, explained.

Splintered legislature, evolving taboos, and new forms of consumption have created a fragmented market for cannabis, and made it challenging for scientists to research its effects on our brains and bodies.

In this episode, we unpack what we know about the cognitive impacts of marijuana use — the good and the bad — and explore new studies which are filling in the gaps.

We discuss:

• The difference between the THC and CBD cannabinoids, and their unique effects on our brains
• How your endocannabinoid system works, and how it's altered under the influence of marijuana
• Why one woman with a genetic mutation that affected her endocannabinoid system couldn't feel pain
• The benefits of marijuana: nausea relief, pain management, and possible uses for reducing seizure frequency and helping with mental health
• The risks of marijuana: memory disorders, addiction, developmental issues, and the dangers of high-potency products that are increasingly difficult to regulate
• Why we first consumed cannabis, about 12,000 years ago

Our incredible guests this week are:

• Dr. Daniele Piomelli, Director of the Institute for the Study of Cannabis at the University of California Irvine
• Dr. Susan Weiss, Director of the Division of Extramural Research at the National Institute on Drug Abuse

'Your Brain On' is hosted by neurologists, scientists and public health advocates Ayesha and Dean Sherzai.

Drs. Ayesha and Dean are now welcoming patients via the Brain Health Institute: https://brainhealthinstitute.com/

'Your Brain On... Marijuana' • SEASON 3 • EPISODE 2

LINKS

Dr. Daniele Piomelli

At University of California Irvine: https://cnlm.uci.edu/piomelli/
UCI Center for the Study of Cannabis: https://cannabis.uci.edu/

Dr. Susan Weiss

National Institute on Drug Abuse: https://nida.nih.gov/
The ABCD Study: https://abcdstudy.org/

FOLLOW US

Join the NEURO Academy: NEUROacademy.com

Instagram: @thebraindocs

Website: TheBrainDocs.com

More info and episodes: TheBrainDocs.com/Podcast

Up next
Nov 5
Your Brain On... Eating Meat
Carnivorous diets have been woven into our history for millennia, but, with nutrition science advancing at an unprecedented pace over the past century... do we really still need to be eating meat? We live in a time of rising chronic disease, new longevity research, and a growing ... Show More
1h 58m
Oct 29
Your Brain On... Nutrition (with Dr. Walter Willett)
Everyone eats. It's the one thing we all have in common. And yet, nutrition has become one of the most confusing, divisive, and misunderstood sciences in modern life. Low-fat. High-fat. Keto. Vegan. Paleo. Superfoods. For every study, there's a headline that seems to say the oppo ... Show More
41m 30s
Oct 22
Your Brain On... Autism
Autism isn't new, but our understanding of it has changed dramatically. It's now recognized as a broad neurodevelopmental spectrum that shapes how millions of people perceive, process, and interact with the world. In this episode, we explore what autism is AND isn't, from its ear ... Show More
1h 52m
Recommended Episodes
Jul 2024
How Cannabis Impacts Health & the Potential Risks | Dr. Matthew Hill
In this episode, my guest is Dr. Matthew Hill, Ph.D., a professor of cell biology and anatomy at the Hotchkiss Brain Institute at the University of Calgary and an expert on the biology of cannabis. We discuss how cannabis affects the brain to produce its psychoactive effects (fee ... Show More
3h 52m
Nov 2024
Why Marijuana Helps Your Brain But Harms Your Mind
The effects of marijuana have long been debated, clearly having both positive and negative effects on its users. Today, Dr K. analyses the research behind the effects of longer term marijuana use on the mind. Check out more mental health resources here! https://bit.ly/3xsk6fE Le ... Show More
33m 37s
May 2024
BONUS EPISODE: Blunt Truths on Marijuana
The cannabis available today is much, much stronger than the weed grandma was smoking back in her day and the effects on our brains are much more significant than previously thought. Really, no really!  Jason and Peter sought out Dr. Ryan Sultan an Assistant Professor of Clinical ... Show More
12m 55s
Jun 2025
Cannabis Scientist: Why Today's Weed Is Dangerous, Highly Addictive & Hard To Quit | Dr. Yasmin Hurd
Dr. Yasmin Hurd is the Director of the Addiction Institute within the Mount Sinai Behavioral Health System as well as the Ward Coleman Chair of Translational Neuroscience and Professor of Psychiatry and Neuroscience at the Icahn School of Medicine at Mount Sinai in New York. Dr. ... Show More
57m 16s
Oct 2024
Episode 332: How Cannabis Affects Sex
<p>A lot of people consume cannabis prior to sexual activity. But how exactly does cannabis affect sex, and what do you need to know about it? In today&#8217;s show, we’re going to dive into what the research says about how cannabis affects men’s and women’s sexual function and p ... Show More
32m 14s
May 2024
Using A Lab On Wheels To Study Weed From Dispensaries
<p>Cannabis is legal in some form or another in over half of US states. But federally, it’s illegal and has no accepted medical use. However, the Biden administration is <a href="https://www.sciencefriday.com/segments/cannavan-lab-cannabis-study/?utm_source=wnyc&utm_medium=podcas ... Show More
17m 57s
Dec 2020
Marijuana: what happens when you quit?
<p>Weed changes your brain, so what happens if you stop? Today we explain what happens when you get stoned, what endocannabinoids do in our body and how they create LEGIT WITHDRAWAL SYMPTOMS!</p> <p>WHAT DID WE LEARN THIS WEEK:</p> <p>5:50 - Human language evolved as GOSSIP!</p> ... Show More
51m 32s
Oct 27
Women's Brain Health: Environment, Hormones, Menopause & Neuronal Pruning with Dr. Sarah McKay
Dr. Sarah McKay, a brilliant neuroscientist, takes us on a thrilling adventure into the intricate dance between hormones and the female brain during menopause. She shares her personal quest to unravel how those mischievous hormonal shifts tweak women's brains from 40 onwards, rev ... Show More
1h 36m
Feb 2025
Dr. Tommy Wood: Enhancing Brain Performance & Preventing Dementia
In this episode, my guest is Dr. Thomas Wood, a UK-trained M.D. with a Ph.D. in physiology and neuroscience. He is a professor of pediatrics and neuroscience at the University of Washington. We discuss how both physical and mental challenges can enhance cognitive function in the ... Show More
3h 3m