Fatigue is a common and debilitating symptom amongst people with kidney failure but remains under appreciated and understudied. Interventions to address fatigue in people with kidney failure requiring dialysis are lacking, highlighted by the lack of recommendations on managing fatigue in clinical practice guidelines. A Cochrane review was published in 2023 summarizing the benefits and harms of pharmacological and non-pharmacological interventions for fatigue in people on dialysis. On this podcast, the review’s first author Dr Patrizia Natale joins us to discuss the study’s findings.