One week ago, Matthew Perry’s autopsy report came back, finding that the ‘Friends’ actor died from the acute effects of ketamine overdose. His death has sharpened focus on the popular and controversial drug. Ketamine has been hailed as a miracle cure for depression and anxiety, criticized as a VC-fueled fad, and investigated as a placebo. But what is ketamin ... Show More
Oct 20
AI Is Smarter Than Ever. So Where’s the Revolution?
AI can analyze anything, write anything, solve almost any puzzle. But struggle strengthens our brains and sharpens our minds ... and removing it entirely may come with a dire cost. Derek Thompson explores the paradoxes of AI with Ethan Mollick, whose new book, 'Co-Existence,' exa ... Show More
1h 7m
Oct 16
How Abundance Has Failed and Succeeded
A year and a half after 'Abundance,' Derek Thompson and Ezra Klein’s book about why America has become so bad at building things, the time has come for reflection. Some commentators declare the abundance agenda dead. If you know where to look, however, you might see a different p ... Show More
1h 2m
Oct 13
America’s Crisis of Social Connection, With Adam Grant
Americans spend more time alone than ever, as parties, nights out with friends, and dinner gatherings become less common. Cellphones, social media, TV, and the internet have made it easier than ever to fill our free time without other people. Research suggests friendship is less ... Show More
1h 3m
Dec 2024
Your Brain On... Ketamine
<p dir="ltr"><strong>For decades, ketamine has mainly been used as an anaesthetic, but in more recent years, it's gained popularity in mental health treatment.</strong></p> <p dir="ltr">Conversations around the benefits and risks associated with its therapeutic usage ignited towa ... Show More
44m 45s
Apr 2023
Ketamine: How Special is Special K?
For years, ketamine has been thought of mostly as a horse tranquilizer — or a street drug that puts you in a scary-sounding K-hole. But now, we’re hearing reports that it could be almost a miracle medicine, treating stubborn depression and other mental illnesses. So how good is i ... Show More
32m 16s
May 2025
What REALLY Happened To Matthew Perry?
<p>In October 2023, actor Matthew Perry died from the acute effects of drugs, with contributing factors including drowning, coronary artery disease, and the effects of buprenorphine. Investigations revealed that Perry's live-in assistant, Kenneth Iwamasa, had been administeri ... Show More
8m 5s
Aug 2023
Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity
In this episode, I explain how ketamine causes rewiring of brain circuits and dissociative states to relieve symptoms of depression and post-traumatic stress disorder (PTSD). I explain how ketamine impacts both the brain’s glutamate and its endogenous opioid pathways, which toget ... Show More
1h 38m
May 2025
How Ketamine is Changing Depression Treatment – Dr. John Krystal Explains
Dr. John Krystal, a leading psychiatrist and neuroscientist, explains how ketamine works in the brain, why it’s revolutionizing depression treatment, and what the future holds for psychedelic-assisted therapy. His journey to discovering the revolutionary benefits of Ketamine trea ... Show More
20m 37s