One week ago, Matthew Perry’s autopsy report came back, finding that the ‘Friends’ actor died from the acute effects of ketamine overdose. His death has sharpened focus on the popular and controversial drug. Ketamine has been hailed as a miracle cure for depression and anxiety, criticized as a VC-fueled fad, and investigated as a placebo. But what is ketamin ... Show More
Sep 1
AI Slop Is Breaking the Internet. Can We Save It?
So many people seem to hate AI, and it’s not just because it might displace millions of jobs, destroy the world, or deepen distrust in big corporations and government. The reason might actually be simpler than we think: People don't like AI because it is so often used to make thi ... Show More
56m 8s
Aug 25
Why Everything Is Going to Keep Getting More Expensive
For much of the 21st century, the U.S. economy was built around cheap money. Today, though, interest rates are rising, and borrowing is getting much more expensive. At the same time, the federal government is running huge deficits while governments and companies around the world ... Show More
41m 54s
Aug 18
Higher Education’s Age of ‘Insufferable Hypocrisy’
It would be an understatement to say that higher education is in crisis, as it faces attacks from both the current presidential administration as well as issues of its own making, like diversity politics. Today, Derek talks with Tyler Austin Harper, author of the viral essay “Con ... Show More
1h 2m
Dec 2024
Your Brain On... Ketamine
<p dir="ltr"><strong>For decades, ketamine has mainly been used as an anaesthetic, but in more recent years, it's gained popularity in mental health treatment.</strong></p> <p dir="ltr">Conversations around the benefits and risks associated with its therapeutic usage ignited towa ... Show More
44m 45s
Apr 2023
Ketamine: How Special is Special K?
For years, ketamine has been thought of mostly as a horse tranquilizer — or a street drug that puts you in a scary-sounding K-hole. But now, we’re hearing reports that it could be almost a miracle medicine, treating stubborn depression and other mental illnesses. So how good is i ... Show More
32m 16s
May 2025
What REALLY Happened To Matthew Perry?
<p>In October 2023, actor Matthew Perry died from the acute effects of drugs, with contributing factors including drowning, coronary artery disease, and the effects of buprenorphine. Investigations revealed that Perry's live-in assistant, Kenneth Iwamasa, had been administeri ... Show More
8m 5s
Aug 2023
Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity
In this episode, I explain how ketamine causes rewiring of brain circuits and dissociative states to relieve symptoms of depression and post-traumatic stress disorder (PTSD). I explain how ketamine impacts both the brain’s glutamate and its endogenous opioid pathways, which toget ... Show More
1h 39m
May 2025
How Ketamine is Changing Depression Treatment – Dr. John Krystal Explains
Dr. John Krystal, a leading psychiatrist and neuroscientist, explains how ketamine works in the brain, why it’s revolutionizing depression treatment, and what the future holds for psychedelic-assisted therapy. His journey to discovering the revolutionary benefits of Ketamine trea ... Show More
20m 37s