One week ago, Matthew Perry’s autopsy report came back, finding that the ‘Friends’ actor died from the acute effects of ketamine overdose. His death has sharpened focus on the popular and controversial drug. Ketamine has been hailed as a miracle cure for depression and anxiety, criticized as a VC-fueled fad, and investigated as a placebo. But what is ketamin ... Show More
Apr 24
The Triple Crisis That’s Breaking Hollywood—and Changing the Future of Movies
Hollywood is in the middle of a triple crisis. You can measure it in tickets, jobs, and ideas. Start with tickets. The best year for the movie business this century was 2002, when Americans and Canadians bought 1.6 billion tickets, or about five per person. Last year, Americans b ... Show More
1h 10m
Apr 21
The Most Powerful and Dangerous AI Model Yet
Two weeks ago, Anthropic announced an AI model so capable and so dangerous that it decided not to release it to the public. The model, codenamed Mythos, could autonomously infiltrate computer systems around the world, exploit security vulnerabilities, conceal its own reasoning, a ... Show More
1h 2m
Apr 14
The Whole World Is Fighting About Energy
The two biggest stories in the world right now—the war involving Iran and the rise of artificial intelligence—are, at their core, the same story: energy. The Iran conflict has become a war of competing energy blockades, with Iran squeezing American allies and America squeezing Ir ... Show More
1h 4m
Dec 2024
Your Brain On... Ketamine
<p dir="ltr"><strong>For decades, ketamine has mainly been used as an anaesthetic, but in more recent years, it's gained popularity in mental health treatment.</strong></p> <p dir="ltr">Conversations around the benefits and risks associated with its therapeutic usage ignited towa ... Show More
44m 45s
May 2025
How Ketamine is Changing Depression Treatment – Dr. John Krystal Explains
Dr. John Krystal, a leading psychiatrist and neuroscientist, explains how ketamine works in the brain, why it’s revolutionizing depression treatment, and what the future holds for psychedelic-assisted therapy. His journey to discovering the revolutionary benefits of Ketamine trea ... Show More
20m 37s
Mar 2025
The New Hit Depression Treatment? A Ketamine-Derived Nasal Spray
After it was approved in 2019, Spravato, a depression treatment derived from the club drug ketamine, was looking like a dud. But recently it has taken off, and it surpassed $1 billion in annual sales last year for its maker, Johnson and Johnson.
Further Listening:
-A Lawyer ... Show More
23m 26s
Aug 2025
Will psychedelics revolutionize mental health treatment? | Matthew Johnson, Shayla Love, and Kevin Sabet
<p><strong>The psychedelic revolution</strong></p><p>Will LSD, Psilocybin, MDMA, and Ketamine treatments live up to the hype?</p><p>For decades, psychedelics were derided as dangerous recreational drugs; now many claim they have the potential to revolutionise the treatment of men ... Show More
49m 34s
Apr 2017
TAP 204 - Robert Whitaker on The Facts And Myths About Antidepressants
<p><strong>Summary:</strong></p> <p id="yui_3_17_2_1_1492473141798_19394">This week we chat with Robert Whitaker about the myths and science behind psychiatric drugs. Robert is the author of five books. In 2010, his <em>Anatomy of an Epidemic: Magic Bullets, Psychiatric Drugs, an ... Show More
1h 10m