In this episode, I explain how ketamine causes rewiring of brain circuits and dissociative states to relieve symptoms of depression and post-traumatic stress disorder (PTSD). I explain how ketamine impacts both the brain’s glutamate and its endogenous opioid pathways, which together regulate mood and well-being. I discuss how ketamine therapy is used clinica ... Show More
Oct 19
What Makes Great Leaders & How to Live an Extraordinary Life | Dr. Jared Diamond
Dr. Jared Diamond, PhD, is a Pulitzer Prize-winning author, physiologist, evolutionary biologist and Professor at UCLA. We discuss the surprising and often chance events that shaped human history and leadership in politics, religion, business and athletics. As one of the most inf ... Show More
1h 53m
Oct 15
Essentials: Neuralink & Technologies to Enhance Human Brains | Dr. Matt MacDougall
In this Huberman Lab Essentials episode, my guest is Dr. Matthew MacDougall, a neurosurgeon at Neuralink. We discuss how brain-machine interfaces could help people with paralysis control computers using their intended movements, and how robotic surgery enables the placement of ti ... Show More
34m 20s
Oct 12
How Food Choices Shape Memory, Cognition & Cravings | Dr. Scott Kanoski
Dr. Scott Kanoski, PhD, is a Professor of Human and Evolutionary Biology and Neurobiology at the University of Southern California. We discuss how different foods impact memory and cognitive function as well as cravings. We also discuss how GLP-1 drugs work to control hunger in t ... Show More
2h 2m
May 2025
How Ketamine is Changing Depression Treatment – Dr. John Krystal Explains
Dr. John Krystal, a leading psychiatrist and neuroscientist, explains how ketamine works in the brain, why it’s revolutionizing depression treatment, and what the future holds for psychedelic-assisted therapy. His journey to discovering the revolutionary benefits of Ketamine trea ... Show More
20m 37s
Apr 2023
Ketamine: How Special is Special K?
For years, ketamine has been thought of mostly as a horse tranquilizer — or a street drug that puts you in a scary-sounding K-hole. But now, we’re hearing reports that it could be almost a miracle medicine, treating stubborn depression and other mental illnesses. So how good is i ... Show More
32m 16s
Dec 2024
Your Brain On... Ketamine
<p dir="ltr"><strong>For decades, ketamine has mainly been used as an anaesthetic, but in more recent years, it's gained popularity in mental health treatment.</strong></p> <p dir="ltr">Conversations around the benefits and risks associated with its therapeutic usage ignited towa ... Show More
44m 45s
Mar 2021
PsychEd Episode 34: Ketamine for Treatment-Resistant Depression with Dr. Sandhya Prashad
Welcome to PsychEd, the psychiatry podcast for medical learners, by medical learners. This episode covers ketamine for treatment-resistant depression (TRD) with Dr. Sandhya Prashad, a psychiatrist and the founder and medical director of Houston Ketamine Therapeutics. She has exte ... Show More
43m 28s
Jul 2025
Psychedelics, Depression, and the Brain: A Breakthrough Framework for Mental Health
What if the key to healing depression isn’t another pill but a profound shift in consciousness? On this episode of The Dr. Hyman Show, I talk with Dr. Robin Carhart-Harris, one of the world’s leading psychedelic researchers, about how these compounds unlock plasticity in the brai ... Show More
1h 34m
Apr 2023
Episode 346: Electroconvulsive Therapy vs Ketamine. Which is better?
<div data-pm-slice="1 1 []" data-en-clipboard="true"> <span data-highlight="green">Hello, friends! In this episode, I tackle one awesome question from a listener. This person has treatment resistant depression and bipolar. Their mania is well-controlled, but they need a higher le ... Show More
27m 36s