In this episode, I explain how ketamine causes rewiring of brain circuits and dissociative states to relieve symptoms of depression and post-traumatic stress disorder (PTSD). I explain how ketamine impacts both the brain’s glutamate and its endogenous opioid pathways, which together regulate mood and well-being. I discuss how ketamine therapy is used clinica ... Show More
Jul 20
Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood
Dr. Tommy Wood, BM, BCh, PhD, is a professor of neuroscience at the University of Washington and an expert on brain health, neuroplasticity, and cognitive performance. Dr. Wood explains how to use specific forms of exercise, dietary strategies, and compounds to enhance the rate a ... Show More
2h 41m
Jul 16
Essentials: The Science & Treatment of Bipolar Disorder
In this Huberman Lab Essentials episode, I explain the biology, symptoms and types of bipolar disorder (sometimes called bipolar depression), a condition characterized by extreme, maladaptive shifts in energy, mood and perception. I describe the diagnostic criteria that distingui ... Show More
35 m
Jul 13
How to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel
Dr. Alan Castel, PhD, is a professor of psychology at the University of California, Los Angeles (UCLA) and one of the world's foremost experts on human memory and cognitive aging. We discuss what science actually tells us about how to improve our learning ability and memory at an ... Show More
2h 28m
May 2025
How Ketamine is Changing Depression Treatment – Dr. John Krystal Explains
Dr. John Krystal, a leading psychiatrist and neuroscientist, explains how ketamine works in the brain, why it’s revolutionizing depression treatment, and what the future holds for psychedelic-assisted therapy. His journey to discovering the revolutionary benefits of Ketamine trea ... Show More
21m 7s
Apr 2023
Ketamine: How Special is Special K?
For years, ketamine has been thought of mostly as a horse tranquilizer — or a street drug that puts you in a scary-sounding K-hole. But now, we’re hearing reports that it could be almost a miracle medicine, treating stubborn depression and other mental illnesses. So how good is i ... Show More
32m 16s
Dec 2024
Your Brain On... Ketamine
<p dir="ltr"><strong>For decades, ketamine has mainly been used as an anaesthetic, but in more recent years, it's gained popularity in mental health treatment.</strong></p> <p dir="ltr">Conversations around the benefits and risks associated with its therapeutic usage ignited towa ... Show More
44m 45s
Mar 2021
PsychEd Episode 34: Ketamine for Treatment-Resistant Depression with Dr. Sandhya Prashad
Welcome to PsychEd, the psychiatry podcast for medical learners, by medical learners. This episode covers ketamine for treatment-resistant depression (TRD) with Dr. Sandhya Prashad, a psychiatrist and the founder and medical director of Houston Ketamine Therapeutics. She has exte ... Show More
43m 28s
Jul 2025
Psychedelics, Depression, and the Brain: A Breakthrough Framework for Mental Health
What if the key to healing depression isn’t another pill but a profound shift in consciousness? On this episode of The Dr. Hyman Show, I talk with Dr. Robin Carhart-Harris, one of the world’s leading psychedelic researchers, about how these compounds unlock plasticity in the brai ... Show More
1h 34m
Apr 2023
Episode 346: Electroconvulsive Therapy vs Ketamine. Which is better?
<div data-pm-slice="1 1 []" data-en-clipboard="true"> <span data-highlight="green">Hello, friends! In this episode, I tackle one awesome question from a listener. This person has treatment resistant depression and bipolar. Their mania is well-controlled, but they need a higher le ... Show More
27m 36s