a16z Podcast: The Scientific Revolution ...

Theo Jaffee speaks with Steven Sinofsky about Apple’s 50th anniversary and the evolution of personal computing over the last four decades. Drawing on his experience helping lead Microsoft through the Windows era, Sinofsky reflects on the cultural differences between Apple and Mic ... Show More

This interview with Stripe cofounders John and Patrick Collison originally aired on TBPN. They discuss Stripe's 34% growth and new employee tender offer, how agent commerce and stablecoins may require high-throughput blockchains built for millions of transactions per second, and ... Show More

Anish Acharya speaks with Peter Yang, creator and product lead at Roblox, about how personal AI agents are replacing the apps we open every day, why coding agents feel like slot machines, and what happens when the cost of building software drops to near zero. They discuss why fut ... Show More

In this episode:0:48 How hominins spread through EuropeAncient stone tools are often uncovered in Europe, but it can be difficult to identify who crafted them, as Neanderthals and Homo sapiens coexisted in the region for several thousand years. The makers of one type of tool foun ... Show More

In 2003, an incredible scientific milestone was achieved as the first human genome completed sequencing. For 20 years, this genome has been used as a reference by researchers for comparison to all other DNA sequences. Now, the Human Pangenome Reference Consortium is addressing th ... Show More

Research into very, very old DNA has made huge leaps forward over the last two decades. That has allowed scientists like Beth Shapiro to push the frontier further and further. "For a long time, we thought, you know, maybe the limit is going to be around 100,000 years [old]. Or, m ... Show More

Fifty thousand years ago, Homo sapiens was not the only species of humans in the world. There were also Neanderthals in what is now Europe, the Near East, and parts of Eurasia; Hobbits (H. floresiensis) on the island of Flores in Indonesia; Denisovans in Siberia and eastern Euras ... Show More

Sir Shankar Balasubramanian is responsible for a revolution in medicine. The method he invented for reading, at speed, the unique genetic code that makes each one of us who we are, is ten million times faster than the technology that was used in the human genome project at the tu ... Show More

James Watson and Francis Crick, who detailed the double-helix structure of DNA in 1953, are perhaps two of the most iconic scientists of the 20th Century. Yet the story of how they made their incredible discovery is perhaps equally famous, with a notorious narrative suggesting th ... Show More

In this episode:00:45 Making a more diverse human genomeThe first draft of the human genome ushered in a new era of genetics research. Since its publication, researchers have constructed ever more accurate ‘reference genomes’ – baselines against which others are compared. But the ... Show More

Big History seeks to retell the human story in light of scientific advances by such methods as radiocarbon dating and genetic analysis. Brian Villmoare's book The Evolution of Everything: The Patterns and Causes of Big History (Cambridge UP, 2023) provides a deep, causal view of ... Show More

On 19th October, a mysterious object sped through our solar system. It was first spotted by astronomers with a telescope in Hawaii. Its trajectory and speed told of its interstellar origins. It is the first body to be detected from outside our solar system. Scientists are now pub ... Show More