Bret speaks with Alexandros Marinos, who has analyzed the TOGETHER trial, which aims to identify effective repurposed therapies to prevent the disease progression of COVID-19.
Alexandros is the Founder/CEO of http://balena.io & aspiring practical philosopher. Find him on:
https://twitter.com/alexandrosm
https://doyourownresearch.substack.com/
Mentioned in this episode:
https://www.togethertrial.com/
https://doyourownresearch.substack.com/p/the-problem-with-the-together-trial
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Theme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.
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Timestamps:
(00:00) Introduction
(03:11) Better Skeptics project – analyzing COVID podcasts
(08:12) TOGETHER trial and its timeline
(15:35) Ads
(19:08) Dosage & initial TOGETHER trial design
(25:29) Confusing paper and placebo group dropout?
(31:23) IVM dose too low and new protocol
(35:04) Trial recruitment over time and key 10-week period
(43:42) Systemic errors
(51:33) Placebo arm from earlier period?
(57:11) Trial data not being released
(01:02:27) Exclusion criteria flipped
(01:06:38) Hypothesis on algorithm rebalancing arms
(01:13:35) Allocation to Fluvoxamine arm
(01:17:12) TOGETHER trial authors believe IVM has an effect
(01:20:15) Credible intervals and Bayesian statistics
(01:25:55) Will we ever get the full story?
(01:30:28) Dosing and weight limit
(01:34:52) Background use of IVM in Brazil
(01:47:19) “Independent” committee monitoring trial
(01:54:29) Cavallo study and inconsistency in response
(01:57:41) Press releases and cold confusion
(02:09:27) Wrap up