In the field of bio-tech, it can take 10 years and millions of dollars to see if an experimental idea might turn into a life-saving treatment—if it ever does. Noubar Afeyan fully understood those risks when he co-founded Moderna in 2010. He and his colleagues were looking for a way to deploy the messenger RNA molecule to tackle life-threatening diseases. In ... Show More
Jul 7
Rick Steves' Europe: Rick Steves (2021)
Rick Steves spent the summer after high school backpacking through Europe on two dollars a day—sleeping on the floor, sneaking into museums, and subsisting on a diet of bread and jam. When he came home, he found people were hungry for tips on how to visit Europe on the cheap, so ... Show More
1h 17m
Jul 3
Advice Line with Jim Koch of Boston Beer Company (August 2024)
Boston Beer Company founder Jim Koch joins Guy on the Advice Line, where they answer questions from three founders about finding product-market fit.Today, we meet Kim, whose tropical-inspired apparel company in Florida is venturing into the rum market. Then Llance from Washington ... Show More
51m 11s
Sep 2021
The Innovation System Behind Moderna’s Covid-19 Vaccine
Noubar Afeyan, cofounder and chair of Moderna Therapeutics and CEO of Flagship Pioneering, says that the breakthrough innovation behind the company’s Covid-19 vaccine came not as a stroke of luck, but from a repeatable process. He outlines a system called “emergent discovery” tha ... Show More
21m 18s
Jan 2022
Guerra de las Vacunas | Esto no es un simulacro | 1
Es prinicpios de enero de 2020, y un misterioso virus nuevo está azotando la ciudad china de Wuhan.Al comienzo, el brote apenas llega a las noticias, pero cuando la amenaza llama la atención, los científicos se ponen en acción para hacer una vacuna. Pero el panorama es sombrío – ... Show More
26m 24s
Jun 2021
Moderna: The Software of Life - [Business Breakdowns, EP. 13]
Today, we will be diving into Moderna. Founded in 2010, Moderna and its innovative RNA platform made headlines after developing one of the first COVID vaccines. We treated this Breakdown slightly different than our other episodes. I’m joined today by two guests. First, I am joine ... Show More
1h 9m
Oct 2021
La course au vaccin | Ceci n’est pas un exercice | 1
Début janvier 2020 : un mystérieux virus vient de faire son apparition dans la ville de Wuhan, au centre de la Chine. Si, au départ, l’épidémie ne fait pas les gros titres, face à sa propagation rapide des scientifiques prennent très vite conscience de la menace que ce virus repr ... Show More
26m 18s
Apr 2021
Vaccine Wars | This is Not a Drill | 1
It’s early January 2020, and a mysterious new virus is overtaking the city of Wuhan, China.At first the outbreak barely makes the news, but as the threat comes into focus, scientists spring into action to make a vaccine. But the outlook’s grim – vaccines take years to create, tes ... Show More
26m 16s
Feb 2022
Paul A. Offit, "You Bet Your Life: From Blood Transfusions to Mass Vaccination, the Long and Risky History of Medical Innovation" (Basic Book, 2021)
Every medical decision—whether to have chemotherapy, an X-ray, or surgery—is a risk, no matter which way you choose. In You Bet Your Life: From Blood Transfusions to Mass Vaccination, the Long and Risky History of Medical Innovation (Basic Book, 2021), physician Paul A. Offit arg ... Show More
42m 2s
Nov 2020
Moderna's chief medical officer on its blockbuster vaccine news
Moderna Therapeutics today reported a 94.5% efficacy for its COVID-19 vaccine, which needn't be stored at the same ultra-cold temperatures as does a similar vaccine developed by Pfizer. It also said short-term safety concerns, such as headaches and injection site soreness, self-r ... Show More
17m 46s