In this week's episode, we’ll start by reviewing an intriguing study that, while not randomized, calls into question whether less-intensive induction therapies provide a survival or quality of life benefit in older patients with AML. Next, we will review the somewhat surprising findings from human and mouse model studies demonstrating that platelets downregu ... Show More
Jul 3
A novel mouse model of sickle cell SC disease; multiple myeloma induction therapy with isatuximab, carfilzomib, lenalidomide, and dexamethasone; and splicing factor mutations in myelodysplastic syndromes
In this week's episode we’ll learn more about a novel mouse model that recapitulates many of the properties of human sickle cell SC disease; results from the induction phase of the risk-adapted MIDAS trial of isatuximab, carfilzomib, lenalidomide, and dexamethasone in newly diagn ... Show More
19m 8s
Jun 26
An AI model for transplant risk in myelofibrosis; preventing priapism in men with sickle cell anemia; hallmarks of T cell exhaustion absent in newly diagnosed MM
In this week's episode, we'll learn about using AI to assess transplant risk in myelofibrosis. In a step toward personalized medicine, researchers report on a machine learning model that identifies 25% of patients with poor outcomes. After that: preventing priapism in men with si ... Show More
18m 24s
Jun 23
Social determinants of health and access to allogeneic hematopoietic cell transplantation, megakaryocyte growth factor receptor-based pretransplant conditioning for ex vivo autologous gene therapy, and novel protein biomarkers for risk stratification in a
In this week's episode, we’ll learn more about social determinants of health that impact access to allogeneic hematopoietic cell transplantation in patients with acute myeloid leukemia, or AML; use of megakaryocyte growth factor receptor-based stem cell depletion as part of pretr ... Show More
19m 38s
Mar 2025
Myelodysplastic Syndrome (MDS)
Ninja Nerds,
Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myelodysplastic Syndrome (MDS), a group of hematologic disorders characterized by ineffective hematopoiesis and a risk of progression to acute myeloid leukemia (AML). We also discuss the ... Show More
26m 35s
Mar 2025
Lymphoma
Ninja Nerds,Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Lymphoma, breaking down its pathogenesis, clinical presentation, and the latest advancements in treatment. We explore the key differences between Hodgkin and Non-Hodgkin Lymphoma, ... Show More
34m 14s
Mar 2023
Do psychological, cognitive, and contextual factors influence rehab outcomes in Achilles tendinopathy?
This week I talk about a feasibility cohort study which sought to determine whether a larger cohort study addressing this question would be feasible. Listen to hear some interesting preliminary findings. Merza, E.Y., Pearson, S.J., Mallows, A.J. and Malliaras, P., 2023. The relat ... Show More
7m 27s
Nov 2024
Genetic Leukodystrophies Mimicking CNS Inflammation - Part 1
In the first part of this two-part series, Dr. Justin Abbatemarco talks with Dr. Jennifer L. Orthmann-Murphy about a practical approach to genetic leukodystrophies, focusing on the importance of genetic testing, identifying red flags in patients, and navigating the complexities o ... Show More
25m 41s
Feb 2025
Myeloproliferative Neoplasia
Ninja Nerds!Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myeloproliferative Neoplasms, covering their pathophysiology, clinical presentation, and management. We discuss Polycythemia Vera, Essential Thrombocythemia, Chronic Myeloid Leukemia, and ... Show More
37m 25s