Sample Size Calculation for a Hypothesis...

The incidence and prevalence of cutaneous melanoma in the US and worldwide have increased over the last 5 decades. JAMA Review Author John Kirkwood, MD, discusses the epidemiology, risk factors, treatment, and prevention of melanoma with JAMA Deputy Editor Kristin Walter, MD, MS. ... Show More

Hemorrhoidal disease, pathology of the tissue lining the anal canal, affects approximately 10 million individuals in the US. Author Jean H. Ashburn, MD, of Wake Forest University School of Medicine and JAMA Senior Editor Karen E. Lasser, MD, MPH, discuss the current evidence on t ... Show More

Dalbavancin, a long-acting IV lipoglycopeptide, may be an option for the treatment of complicated Staphylococcus aureus bacteremia without requiring long-term IV access. Author Thomas L. Holland, MD, MSc, from Duke University School of Medicine discusses key points of the DOTS ra ... Show More

One of the most common causes for problems we see in manuscripts at JAMA is an inappropriately calculated study sample size. This seemingly mysterious process is explained by Lynne Stokes, PhD, professor of Statistical Science at Southern Methodist University in Dallas, Texas. 

In this "Breathe Easy Critical Perspective" podcast, Dr. Dominique Pepper interviews Dr. Michael Sjoding. They discuss his NEJM publication about bias in pulse oximetry measurement. Dr. Sjoding is an Assistant Professor in the Division of Pulmonary and Critical Care at the Univer ... Show More

One of the hottest topics in modern physics is trying to understand the scattering of fundamental particles with neither shape nor size - one step up from nothingness. Amazingly, attempts to understand these simple processes theoretically require state-of-the-art mathematics. The ... Show More

Tomas Kalincik, Head of the Clinical Outcomes Research Unit at the University of Melbourne, and Maria Pia Sormani, Professor of Biostatistics at the University of Genoa, discuss the use of real-world data to compare disease-modifying treatments (DMTs) in multiple sclerosis, inclu ... Show More

Eric Larson and Isabel Vogt have solved the interpolation problem — a centuries-old question about some of the most basic objects in geometry. Some credit goes to the chalkboard in their living room. Read more at QuantaMagazine.org. Music is “Good Times” by Patrick Patrikios. 

Kelley Kidwell, PhD, professor of biostatistics, University of Michigan, discusses Sequential, Multiple Assignment, Randomized Trial Designs with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Sequential, Multiple Assignment, Randomized Trial Designs 

A.J. Holmgren, PhD, an assistant professor in the department of medicine at UC San Francisco, discusses EHR quality measurement, quality of care and patient outcomes. This episode is part of the Health IT series by the AMA-MSS Committee on Health Information Technology, hosted by ... Show More

Our guest in this episode is Sebastien Motsch, an assistant professor at Arizona State University, working in the School of Mathematical and Statistical Science. He works on modeling self-organized biological systems to understand how complex patterns emerge. 

The t-test is this week's mini-episode topic. The t-test is a statistical testing procedure used to determine if the mean of two datasets differs by a statistically significant amount. We discuss how a wine manufacturer might apply a t-test to determine if the sweetness, acidity, ... Show More