a16z Podcast: The Biology of Pain

As governments weigh new restrictions on frontier AI models, one question is becoming increasingly important: what role should open source play in the future of artificial intelligence? Theo Jaffee and Sofia Puccini speak with Hugging Face CEO Clément Delangue about AI regulation ... Show More

This interview with Stripe cofounders John and Patrick Collison originally aired on TBPN. They discuss Stripe's 34% growth and new employee tender offer, how agent commerce and stablecoins may require high-throughput blockchains built for millions of transactions per second, and ... Show More

Anish Acharya speaks with Peter Yang, creator and product lead at Roblox, about how personal AI agents are replacing the apps we open every day, why coding agents feel like slot machines, and what happens when the cost of building software drops to near zero. They discuss why fut ... Show More

How do we feel pain? What parts of the brain control our reaction to painful sensations? And how is stem cell technology revolutionising the search for better treatments for chronic pain? In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she u ... Show More

Pain has long been recognised as something of an enigma by scientists and clinicians. It's both a measurable physiological process, as well as deeply personal and subjective. Claudia Hammond meets scientists attending the British Neuroscience Association's Christmas symposium on ... Show More

<p>Stanford neuroscientist Sean Mackey, MD, PhD reveals pain is highly subjective, shaped by our beliefs and experiences - not just injury signals. He unpacks chronic pain's persistence, promising treatment strategies like brief behavioral therapies, and research toward personali ... Show More

In this episode, Dillon and Sherif discuss everything related to the most complex sensation we experience, pain. What is pain? Why do we feel pain? What are the different types of pain? Is pain typically viewed as a good thing or a bad thing? The guys also discuss previous scient ... Show More

Thirty years into the opioid crisis, we still struggle to find other options for pain relief. This hour, TED speakers explain new understandings of how the brain interprets pain and new ideas to cope. Guests include equestrian Kat Naud, physician and researcher Amy Baxter and opi ... Show More

<p>In recent decades we’ve come to understand that there’s a lot more to pain than: touch hot stove/feel burning hand. Pain is a far more sophisticated experience and, unfortunately, a system that can often go haywire, with terrible effects.</p><p> </p> Learn more about your ad-c ... Show More

This episode I discuss our sense of pain and pleasure: where and how they each arise in our mind and body and various ways to control their intensity. I discuss the science of behavioral tools like acupuncture and hypnosis and directed pressure, including the neural circuits they ... Show More

In this episode, I describe the science of how and why pain arises in the body and brain, and how we can actively control our experience of pain. I discuss inflammation, stress, acupuncture, limb damage and Traumatic Brain Injury (TBI). I review protocols that leverage the lympha ... Show More

<p>PAIN. What is it? Where does it come from? And how can we hurt less? Which hurts more, a kidney stone or heartache? Why does chronic pain persist? Can we turn down our pain dials? To answer these huge questions, pain psychologist Dr. Rachel Zoffness enthusiastically explains t ... Show More