Gregorio Allegri wrote the chord sequence for his Miserere in the 1630s for use during Holy Week in the Sistine Chapel.
This is located in the Apostolic Palace, official residence for the Pope in Vatican City
It then went through the hands of a 12-year-old Mozart, Mendelssohn and Liszt until it finally reached England in the early 20th century and got fixed into the version we know today.
The soaring soprano line that hits the famous top C and never fails to thrill has become a firm favourite for concert audiences around the world.
Textile designer Kaffe Fassett, writer Sarah Manguso and conductor Roy Goodman explain how they have all been deeply affected by this beautiful piece of music.
With Peter Phillips.
Series exploring famous pieces of music and their emotional appeal.
Producer: Rosie Boulton
First broadcast on BBC Radio 4 in September 2009.