Orphan Drugs

Articles of Interest host Avery Trufelman joins Roman to tell the incredible story of the American military’s jacket problem: How should the military outfit its soldiers to make them as safe and effective as possible? The answer was the M43 Field Jacket, which not only changed wh ... Show More

Every product has to be tested somehow, and sometimes that means finding increasingly creative ways to break it. Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siri ... Show More

This episode is sponsored by Claude. For problems worth solving, get started with Claude at Claude.ai. If you watched Wheel of Fortune in the 1980s, you probably remember one prize more than all the others: the ceramic Dalmatian. For a brief moment, that prize—perhaps the ultimat ... Show More

In the first of two episodes this week, we're taking a deep dive into the pharmaceutical industry. How much does the medication you take actually cost? What if a company came along and bought the rights to a particular drug and started charging double, triple, or even 10,000 time ... Show More

When you get hurt, you go to a doctor. But what do you do when your doctor’s prescriptions turn you into an opioid addict? Johnny Simon and Tim Cronin tried one of the first legal battles in America to hold physicians accountable for over-prescribing opioids. And they won. Johnny ... Show More

This is a story of desperation, anger, poverty—and triumph over long odds to crack the code of a degenerative disease that had been stealing the lives of children since it was first discovered more than a century ago. Learn more about your ad choices. Visit megaphone.fm/adchoices 

<p>In the 1950s, Thalidomide was rolled out very quickly and what followed was a tragic story that highlighted perils of greed and hidden agendas. This week on Sawbones, Dr. Sydnee and Justin attempt to untangle this murky narrative, and highlight the doctor who heroically kept t ... Show More

At the beginning of the 20th century, new medications were being discovered and created. The term ‘miracle drug’ was coined to describe the sudden positive effect of newly discovered remedies for once untreatable diseases and conditions. But, one person's cure can be another pers ... Show More

<p>In this episode, Pharmageddon, we plunge into the depths of the pharmaceutical underworld, exposing a web of corruption, clandestine dealings, and the puppet masters behind Big Pharma. The narrative unfolds as investigative journalists peel back layers of secrecy, revealing a ... Show More